MSRB3 Antibody

說明書

中文名稱：

MSRB3兔多克隆抗體
貨號：

CSB-PA810290DSR1HU
規格：

￥440
圖片：
Western blot
All lanes: MSRB3 antibody at 4.61 μg/ml
Lane 1: Mouse large intestine tissue
Lane 2: Mouse lung tissue
Lane 3: Mouse gonadal tissue
Lane 4: Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MSRB3 Polyclonal antibody
Uniprot No.：

Q8IXL7
基因名：

MSRB3
別名：

Deafness, Autosomal Recessive 74 antibody; DFNB74 antibody; FLJ36866 antibody; Methionine R sulfoxide reductase B mitochondrial antibody; Methionine sulfoxide reductase B3 antibody; Methionine-R-sulfoxide reductase B3 antibody; MsrB3 antibody; MSRB3_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Methionine-R-sulfoxide reductase B3 protein (1-185AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
基因功能參考文獻：
1. we characterise the mammalian enzyme Msr B3. There are two splice variants of this enzyme that differ only in their N-terminal signal sequence, which directs the protein to either the endoplasmic reticulum (ER) or mitochondria PMID: 29420254
2. This characterization of GWAS-implicated MSRB3 protein expression in human hippocampus suggests that patterns of neuronal and vascular MsrB3 protein expression reflect or underlie pathology associated with Alzheimer disease. PMID: 28777754
3. Oncogene induction in differentiated cells induces massive DNA damage, mammary stem cells are resistant, owing to a preemptive program driven by ZEB1 and MSRB3. The prevention of oncogene-induced DNA damage precludes induction of the oncosuppressive p53-dependent DNA-damage response, thereby increasing stem cells' intrinsic susceptibility to malignant transformation. PMID: 28394329
4. The data suggest that MsrB3 attenuates HO-1 induction by inhibiting reactive oxygen species production, endoplasmic reticulum stress, and Nrf2 activation. PMID: 27059143
5. MsrB3 plays an important role in cancer cell survival through the modulation of the intrinsic apoptosis pathway. PMID: 28007593
6. Taken together, our results suggest that MsrB3 plays a critical role in cancer cell apoptosis through the modulation of ER stress status. PMID: 28389299
7. MsrB3 deficiency activates the cell cycle inhibitors p21 and p27. PMID: 24583268
8. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. PMID: 22422452
9. these data provide evidence that the ER-type of MsrB3 plays an important role in protection against ER stress, suggesting that MsrB3 may be involved in the regulation of ER homeostasis. PMID: 22405767
10. Taken together, these data provide evidence that the ER type of MsrB, MsrB3A, plays an important role in protection mechanisms against oxidative, cold and heat stresses and, moreover, in the regulation of fruit fly aging. PMID: 22310715
11. Results identified an antimicrobial peptide from the human methionine sulfoxide reductase B3 protein. PMID: 22027001
12. an in vitro assay revealed that p.Cys89Gly completely abolished MSRB3 enzymatic activity and that p.Arg19X is a null allele for MSRB3 mitochondrial isoforms, indicating that DFNB74 deafness might be a mitochondrial disease limited to the inner ear. PMID: 21185009
13. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195514
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相關疾病：

Deafness, autosomal recessive, 74 (DFNB74)
亞細胞定位：

[Isoform 1]: Endoplasmic reticulum.; [Isoform 2]: Mitochondrion.
蛋白家族：

MsrB Met sulfoxide reductase family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 27375

OMIM: 613718

KEGG: hsa:253827

STRING: 9606.ENSP00000347324

UniGene: Hs.339024

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