MSRB1 Antibody, FITC conjugated
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中文名稱：MSRB1兔多克隆抗體, FITC偶聯
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貨號：CSB-PA882163LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MSRB1 Polyclonal antibody
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Uniprot No.：
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基因名：MSRB1
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別名：Annexin A2 like antibody; EC 1 8 4 antibody; HSPC 270 antibody; HSPC270 antibody; Methionine R sulfoxide reductase antibody; Methionine R sulfoxide reductase B1 antibody; Methionine sulfoxide reductase antibody; Methionine-R-sulfoxide reductase B1 antibody; MGC3344 antibody; MSRB 1 antibody; MsrB1 antibody; MSRB1_HUMAN antibody; OTTHUMP00000159418 antibody; Sel X antibody; Selenoprotein R antibody; Selenoprotein X 1 antibody; Selenoprotein X antibody; Selenoprotein X1 antibody; SELR antibody; SelX antibody; SEPX 1 antibody; sepx1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Methionine-R-sulfoxide reductase B1 protein (1-116AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
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基因功能參考文獻：
- In vivo, MsrB1 shRNAi can inhibit lung metastasis in metastasis model. In conclusion, MsrB1 regulates proliferation and invasion of u2os cells by affecting MAPK pathway and EMT, and MsrB1 gene may be a novel therapeutic target against tumors. PMID: 29395081
- FRET and co-IP assays demonstrated that Clu interacted with beta-amyloid peptide, a pathological protein of AD, which suggested a potential effect of SelR and Abeta with the aid of Clu. The interaction between SelR and Clu provides a novel avenue for further study on the mechanism of SelR in AD prevention. PMID: 23805218
- MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption. PMID: 24342607
- findings suggested that SelX played important roles in protecting LO2 cells against oxidative damage and reducing H2O2-induced apoptosis in liver cells. PMID: 26899321
- Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress PMID: 26875981
- Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress. PMID: 23988788
- MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption PMID: 24342607
- MsrB1 plays important roles in protecting HLE cell mitochondria against oxidative damage and inhibits oxidative stress-induced apoptosis in diabetic cataracts by scavenging ROS. PMID: 23270945
- The results demonstrate that in human lens epithelial cells MsrB1 may play important roles in regulating redox balance and mitigating endoplasmic reticulum stress. PMID: 22713178
- Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 21048031
- The neutrophils expressed the highest activity Msrs. Msrs are important as antioxidant/repair systems for neutrophils, cells with enormous capacity for the generation of reactive oxidants and hence, susceptible to oxidative damage. PMID: 17938273
- Strong candidate gene for schizophrenia; upregulated in lymphoblastoid cells of monozygotic twins. PMID: 18081029
- The studies in mouse show that MsrB is a selenoprotein that exhibits high specificity for reduction of the R forms of free and protein-bound methionine sulfoxide. PMID: 11779133
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亞細胞定位：Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.
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蛋白家族：MsrB Met sulfoxide reductase family
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數據庫鏈接：
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