MSL2 Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MSL2 Polyclonal antibody
Uniprot No.：

Q9HCI7
基因名：

MSL2
別名：

Male specific lethal 2 homolog (Drosophila) antibody; Male specific lethal 2 homolog 1 antibody; Male specific lethal 2 homolog antibody; Male specific lethal 2 like 1 antibody; Male-specific lethal 2 homolog antibody; Male-specific lethal 2-like 1 antibody; Male-specific lethal-2 homolog 1 antibody; MSL-2 antibody; MSL2 antibody; MSL2-like 1 antibody; MSL2_HUMAN antibody; MSL2L1 antibody; Ring finger protein 184 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase MSL2 protein (341-473AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MSL2 Antibody (CSB-PA875722LA01HU)，的標記方式是Non-conjugated。對于MSL2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA875722LB01HU	MSL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA875722LC01HU	MSL2 Antibody, FITC conjugated
Biotin	CSB-PA875722LD01HU	MSL2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
基因功能參考文獻：
1. HBx-elevated MSL2 modulates hepatitis B virus (HBV) cccDNA in hepatoma cells to promote hepatocarcinogenesis, forming a positive feedback loop of HBx/MSL2/cccDNA/HBV. PMID: 28608964
2. Msl2 is a novel component of the vertebrate DNA damage response. PMID: 23874665
3. MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34. PMID: 21726816
4. A multisubunit human histone acetylase complex that contains homologs of the Drosophila MSL proteins MOF, MSL1 (hampin A), MSL2, and MSL3 was described. This complex is responsible for histone H4 lysine-16 acetylation of all cellular chromosomes. PMID: 16227571
蛋白家族：

MSL2 family
數據庫鏈接：

HGNC: 25544

OMIM: 614802

KEGG: hsa:55167

STRING: 9606.ENSP00000311827

UniGene: Hs.18631

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