MRPL58 Antibody

中文名稱：

MRPL58兔多克隆抗體
貨號：

CSB-PA613490HA01HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: MRPL58 antibody at 2µg/ml
Lane 1: A549 whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 24 kDa
Observed band size: 24 kDa

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA613490HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA613490HA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MRPL58 Polyclonal antibody
Uniprot No.：

Q14197
基因名：

MRPL58
別名：

Digestion substraction 1 antibody; DS-1 antibody; DS1 antibody; Ict1 antibody; ICT1_HUMAN antibody; Immature colon carcinoma transcript 1 antibody; Immature colon carcinoma transcript 1 protein antibody; mitochondrial antibody; Peptidyl-tRNA hydrolase ICT1 antibody; Peptidyl-tRNA hydrolase ICT1, mitochondrial antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Peptidyl-tRNA hydrolase ICT1, mitochondrial protein (30-206AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，MRPL58 Antibody (CSB-PA613490HA01HU)，的標(biāo)記方式是Non-conjugated。對于MRPL58 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA613490HB01HU	MRPL58 Antibody, HRP conjugated	ELISA
FITC	CSB-PA613490HC01HU	MRPL58 Antibody, FITC conjugated
Biotin	CSB-PA613490HD01HU	MRPL58 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
基因功能參考文獻：
1. High ICT1 expression is associated with leukemia. PMID: 29328466
2. ICT1 overexpression notably predicted poor prognosis of gastric cancer patients. PMID: 28987942
3. Study demonstrates that ICT1 overexpression correlates with malignant clinical features and poor prognosis of hepatocellular carcinoma (HCC) patients. Functionally, ICT1 promotes proliferation, cell cycle progression and inhibits apoptosis of HCC cells. ICT1 regulates the expressions of CDK1, cyclin B1, Bcl-2 and Bax, and is directly targeted by microRNA-134 (miR-134) in HCC cells. PMID: 29130100
4. ICT1 may play a crucial role in promoting gastric cancer proliferation in vitro. PMID: 29036264
5. The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity. PMID: 28826487
6. our preliminary study reveals the important role of ICT1 in NSCLC cells that knockdown of ICT1 significantly suppressed cell proliferation, arrested cell cycle though altering expression cell cycle regulators, and promoted cell apoptosis. PMID: 27413166
7. ICT1 knockdown significantly inhibited cell proliferation and migration, led to G2/M phase cell-cycle arrest, and triggered apoptosis via the intracellular AMPKa, SAPK/JNK, and PARP signaling pathways. PMID: 27411551
8. ICT1 was significantly upregulated in diffuse large B-cell lymphoma tissues (DLBCL) and correlated with poor survival. Knockdown of ICT1 remarkably induced cell cycle G0/G phase arrest and apoptosis in DLBCL cells. PMID: 28629825
9. ICT1 knockdown altered the expression of apoptosis- or cell cyclerelated proteins such as Bcl-2, caspase-3, CDK1, CDK2 and cyclin B. PMID: 28290601
10. ICT1 may be essential for hydrolysis of prematurely terminated peptidyl-tRNA moieties in stalled mitoribosomes. PMID: 20186120
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亞細胞定位：

Mitochondrion.
蛋白家族：

Prokaryotic/mitochondrial release factor family, Mitochondrion-specific ribosomal protein mL62 subfamily
組織特異性：

Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.
數(shù)據(jù)庫鏈接：

HGNC: 5359

OMIM: 603000

KEGG: hsa:3396

STRING: 9606.ENSP00000301585

UniGene: Hs.407955

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