MRAP Antibody, FITC conjugated
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中文名稱：MRAP兔多克隆抗體, FITC偶聯
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貨號：CSB-PA851545LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MRAP Polyclonal antibody
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Uniprot No.：
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基因名：MRAP
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別名：B27 antibody; C21orf61 antibody; FALP antibody; Fat cell-specific low molecular weight protein antibody; Fat tissue-specific low MW protein antibody; FGD2 antibody; GCCD2 antibody; Melanocortin-2 receptor accessory protein antibody; Mrap antibody; MRAP_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Melanocortin-2 receptor accessory protein (59-172AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.
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基因功能參考文獻：
- allele of the 5 insertion/deletion polymorphism in the Alpha-2-MRAP gene is related with an increase of oxidative stress in nephrolithiasis patients PMID: 28760704
- Data (including data from studies in transgenic mice) suggest that MRAP plays critical role in (1) regulation of lipolysis in adipose tissue, (2) regulation of enzyme expression in adipose tissue, and (3) whole-body energy balance. PMID: 29217655
- MRAP expression in human cell line results in an ACTH responsive phenotype. PMID: 26576642
- Data show that co-expression with MRAPalpha, but not MRAP2, enhances MC4R constitutive activity. MRAPalpha-enhanced MC4R constitutive activity is not dependent on MC4R complex glycosylation but may result from MRAPalpha-induced changes in MC4R conformational states. PMID: 26469516
- The results firmly establish that only the copy of MRAP oriented with the amino terminus on the extracellular side of the receptor is essential for Adrenocorticotropic Hormone signal transduction. PMID: 26424796
- Data suggest that MRAP regulates expression of melanocortin receptors (MC1R-MC5R); MRAP is highly expressed in both zona fasciculata and undifferentiated zone of adrenal gland, sites of MC2R-mediated adrenal steroidogenesis. [REVIEW] PMID: 23418361
- The data suggest that MRAPalpha is involved in MC2R targeting to the plasma membrane, while MRAPbeta may enhance ACTH-MC2R coupling to cAMP production. PMID: 22366472
- MRAP is positively regulated by ACTH and AngII in human adrenocortical tissues. PMID: 22419722
- A novel MRAP mutation is identified in a neonate where disruption of intron 3 splice-site results in a prematurely terminated translation product causing complete lack of adrenocorticotrophic (ADTH) hormone receptor response. PMID: 21951701
- The MRAP promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
- ACTH binding to MC2R stimulates PKA-dependent p44/p42(mapk) phosphorylation. PMID: 21195128
- study shows that novel missense mutations in MRAP are associated with a milder, late onset phenotype in two families with familial glucocorticoid deficiency PMID: 20427498
- Data show that tall stature is associated with mutations in MC2R but not in MRAP. PMID: 19558534
- No mutations in MC2R, MRAP or STAR were identified in any patient with Addison's disease PMID: 19903795
- We identified mutations in a protein, now known as melanocortin 2 receptor accessory protein (MRAP). We show that MRAP interacts with MC2R and may have a role in the trafficking of MC2R from the endoplasmic reticulum to the cell surface. PMID: 15654338
- MC2R-green fluorescent protein fusion transfected with either MRAPalpha or MRAPbeta was impaired both in cell membrane localization and signaling. PMID: 17456795
- Familial glucocorticoid deficiency type 2, confirmed by a mutation of the MRAP gene. PMID: 17893271
- MRAP is the first eukaryotic membrane protein identified with an antiparallel homodimeric structure. PMID: 18077336
- The transmembrane domain of MRAP is the MC2R interaction domain and a conserved N-terminal tyrosine-rich domain of MRAP is required for trafficking MC2R to the cell surface. PMID: 18818285
- MRAP not only facilitates MC2 receptor trafficking but also allows properly localized receptor to bind ACTH and consequently signal. PMID: 18981183
- identify MRAP and MRAP2 as unique bidirectional regulators of the melanocortin receptor family PMID: 19329486
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相關疾病：Glucocorticoid deficiency 2 (GCCD2)
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亞細胞定位：Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
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蛋白家族：MRAP family
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組織特異性：Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues.
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數據庫鏈接：
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