MR1 Antibody, FITC conjugated

說明書

中文名稱：

MR1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA853268LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MR1 Polyclonal antibody
Uniprot No.：

Q95460
基因名：

MR1
別名：

Class I histocompatibility antigen like protein antibody; Class I histocompatibility antigen-like protein antibody; HLALS antibody; HMR1_HUMAN antibody; Major histocompatibility complex class I like sequence antibody; Major histocompatibility complex class I related antibody; Major histocompatibility complex class I related gene protein antibody; Major histocompatibility complex class I related isoform CRA a antibody; Major histocompatibility complex class I related isoform CRA c antibody; Major histocompatibility complex class I related isoform CRA d antibody; Major histocompatibility complex class I-related gene protein antibody; MHC class I like antigen MR 1 antibody; MHC class I like antigen MR1 antibody; MHC class I related gene protein antibody; MHC class I related protein 1 isoform B antibody; MHC class I related protein 1 isoform C antibody; MHC class I-related gene protein antibody; MR 1 antibody; Mr1 antibody; Mr1 protein antibody; MR1B antibody; MR1C antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Major histocompatibility complex class I-related gene protein (150-253AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers. Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively. May present microbial antigens to various TRAV1-2-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells. During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora. Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR consisting of TRAV38.2-DV8*TRAJ31 alpha chain paired with a TRBV25.1*TRBJ2.3 beta chain on a non-MAIT CD8-positive T cell clone (MC.7.G5), triggering T cell-mediated killing of a wide range of cancer cell types.
基因功能參考文獻：
1. Human mucosal-associated invariant T cells possess capacity for B cell help via MR1-mediated immunoglobulins production. PMID: 28807929
2. Early endosomal TLR9 activation is important for MR1-mediated bacterial antigen presentation in B cells. PMID: 28518215
3. Polymorphism in MR1 gene is associated with susceptibility to tuberculosis. PMID: 27881839
4. we have shown that MR1-mediated MAIT cell activation is tightly regulated at several levels. Efficient MR1-mediated MAIT cell activation requires both intact bacteria to access an acidified endolysomal compartment and activation of the APC through NF-kappaB or interferon signaling pathways. PMID: 27105778
5. results suggest that high expression of MR-1 is involved in hepatocellular carcinoma progression PMID: 26823810
6. Data show that the major histocompatibility complex, class I-related protein (MR1) antigen presentation is characterized by a rapid 'off-on-off' mechanism that is strictly dependent on antigen availability. PMID: 27043408
7. endosome-mediated trafficking of MR1 allows for selective sampling of the intracellular environment PMID: 27031111
8. Studies indicate that the antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. PMID: 26388332
9. Data indicate that high expression of CD26 ia a specific markers to define major histocompatibility complex, class I-like sequence protein MR1-restricted mucosa-associated invariant T (MAIT) cells. PMID: 25752900
10. Mucosal-associated invariant T cell adaptation was a direct consequence of exposure to various exogenous MR1-restricted epitopes. PMID: 25049333
11. [review] Mucosal-associated invariant T-cell (MAIT) T-cell antigen receptor recognizes riboflavin and folic acid metabolites bound by MR1 in a conserved docking mode and thus acts like a pattern recognition receptor. PMID: 24556396
12. MR1 tetramers allow precise phenotypic characterization of human and mouse mucosal-associated invariant T cells. PMID: 24101382
13. A novel MR1B isoform probably plays a physiological role complementary to MR1A with respect to mucosal-associated invariant T cells development and/or function. PMID: 23457030
14. Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress. PMID: 22692454
15. metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance; as many vitamin biosynthetic pathways are unique to bacteria and yeast, data suggest that MAIT cells use these metabolites to detect microbial infection PMID: 23051753
16. Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation PMID: 22412157
17. Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface. PMID: 21777569
18. fact that MR1 seems mainly intracellular might offer clues as to the process, given the precedence in other class I molecules PMID: 21190736
19. MR1 molecules can associate with the peptide-loading complex and can be detected at low levels at the surface of transfected cells. PMID: 12794138
20. Our results demonstrated a preferential association of MR1 with beta(2)-microglobulin in MHC class I-deficient B cell lines. PMID: 18068122
21. the presentation pathway of MR1 to MAIT cells is highly evolutionarily conserved PMID: 19416870
22. Induction of MHC class I-like antigen is associated with relapsed chronic myeloid leukemia. PMID: 19706888
23. a function for MR1 in the development of IgA producing plasma cells. PMID: 19760593
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.; [Isoform 4]: Secreted.
蛋白家族：

MHC class I family
組織特異性：

Ubiquitous. Low expression is detected in peripheral blood B cells, T cells, monocytes and in bronchial epithelial cells (at protein level). Expressed in plasmablasts or plasma B cells in the lamina propria of ileum, appendix and colon (at protein level).
數據庫鏈接：

HGNC: 4975

OMIM: 600764

KEGG: hsa:3140

STRING: 9606.ENSP00000356552

UniGene: Hs.13500

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