MPI Antibody, HRP conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MPI Polyclonal antibody
Uniprot No.：

P34949
基因名：

MPI
別名：

ody; CDG1B antibody; FLJ39201 antibody; Mannose 6 phosphate isomerase antibody; Mannose-6-phosphate isomerase antibody; MANNOSEPHOSPHATE ISOMERASE antibody; MGC94106 antibody; MPI antibody; MPI_HUMAN antibody; Phosphohexomutase antibody; phosphomannose isomerase 1 antibody; Phosphomannose isomerase antibody; PMI antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Mannose-6-phosphate isomerase protein (213-350AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
基因功能參考文獻(xiàn)：
1. This work provides mechanistic evidence by which mannose phosphate isomerase loss induces p53, and identifies mannose phosphate isomerase as a novel regulator of p53 and Warburg metabolism. PMID: 28644127
2. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts PMID: 21949237
3. The mannose-6-phosphate-enzyme complex is developed and the key residues involved in the ligand binding are determined. Our results suggest a hydride transfer mechanism of alpha-hydrogen between the C1 and C2 positions. PMID: 16488169
相關(guān)疾病：

Congenital disorder of glycosylation 1B (CDG1B)
亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

Mannose-6-phosphate isomerase type 1 family
組織特異性：

Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
數(shù)據(jù)庫鏈接：

HGNC: 7216

OMIM: 154550

KEGG: hsa:4351

STRING: 9606.ENSP00000318318

UniGene: Hs.75694

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