MOB1B Antibody

說明書

產品詳情

Uniprot No.：

Q7L9L4
基因名：

MOB1B
別名：

MATS 2 antibody; MATS2 antibody; MGC33910 antibody; Mob 1A antibody; Mob 1B antibody; MOB 4A antibody; MOB kinase activator 1B antibody; Mob1 homolog 1A antibody; MOB1 Mps One Binder homolog B antibody; MOB1 Mps one binder kinase activator like 1A antibody; Mob1A antibody; Mob1B antibody; MOBKL 1A antibody; MOBKL1A antibody; MOL1A_HUMAN antibody; Mps one binder kinase activator like 1A antibody; Mps one binder kinase activator-like 1A antibody; Protein Mob4A antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Monkey
免疫原：

Synthesized peptide derived from the Internal region of Human Mob1A.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

MOB1/phocein family
組織特異性：

Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.
數據庫鏈接：

HGNC: 29801

OMIM: 609282

KEGG: hsa:92597

STRING: 9606.ENSP00000310189

UniGene: Hs.691454

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