MMP25 Antibody

說明書

中文名稱：

MMP25兔多克隆抗體
貨號：

CSB-PA926432
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA926432(MMP25 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA926432(MMP25 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: 823 cells, Primary antibody: CSB-PA926432(MMP25 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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靶點詳情

產品詳情

Uniprot No.：

Q9NPA2
基因名：

MMP25
別名：

Leukolysin antibody; matrix metallopeptidase 25 antibody; matrix metallopeptidase like 1 antibody; matrix metalloproteinase 20 antibody; Matrix Metalloproteinase 25 antibody; Matrix metalloproteinase 25 precursor antibody; Matrix metalloproteinase-25 antibody; Membrane type 6 Matrix Metalloproteinase antibody; Membrane type Matrix Metalloproteinase 6 antibody; Membrane-type matrix metalloproteinase 6 antibody; Membrane-type-6 matrix metalloproteinase antibody; MMP 25 antibody; MMP-25 antibody; MMP20 antibody; MMP20A antibody; MMP25 antibody; MMP25_HUMAN antibody; MMPL1 antibody; MT MMP 6 antibody; MT-MMP 6 antibody; MT6 MMP antibody; MT6-MMP antibody; MT6MMP antibody; MTMMP6 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human MMP25
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May activate progelatinase A.
基因功能參考文獻：
1. In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis. PMID: 24669030
2. IL-2-upregulated MT6 cell-surface expression correlates with CD16 downmodulation. MT6, sequestered in intracellular compartments in unstimulated NK cells, translocates to the effector-target cell interface of CD16-mediated immunological synapses. PMID: 23851692
3. MT6-MMP regulates neutrophil and monocyte chemotaxis and by generating "eat-me" signals upon vimentin cleavage potentially increases phagocytic removal of neutrophils to resolve inflammation. PMID: 22367194
4. MT6-MMP is present in the membrane, granules and nuclear/endoplasmic reticulum/Golgi fractions of PMNs where it is displayed as a disulfide-linked homodimer of 120 kDa PMID: 20501611
5. individuals with history of chronic airways inflammation (asthma and COPD) serum leukolysin may be a metabolic marker associated with chronic atopy-associated respiratory inflammation. PMID: 20337648
6. Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase. PMID: 20308072
7. MMP25 is regulated by clusterin in vivo PMID: 12860995
8. MT6-MMP may play a role in colon cancer and exhibit unique biochemical and structural properties that may regulate proteolytic function at the cell surface. PMID: 17513868
9. the stem region of MT6-MMP is the dimerization interface, an event whose outcome imparts protease stability to the protein PMID: 18936094
10. MMP-25 plays an important role in multiple sclerosis pathology PMID: 19726693
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
蛋白家族：

Peptidase M10A family
組織特異性：

Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.
數據庫鏈接：

HGNC: 14246

OMIM: 608482

KEGG: hsa:64386

STRING: 9606.ENSP00000337816

UniGene: Hs.654979

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