MLXIPL Antibody
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中文名稱：MLXIPL兔多克隆抗體
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貨號：CSB-PA014645GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：carbohydrate response element binding protein antibody; bHLHd14 antibody; Carbohydrate responsive element binding protein antibody; Class D basic helix-loop-helix protein 14 antibody; MIO antibody; MLX interacting protein like antibody; Mlx interactor antibody; MLX-interacting protein-like antibody; MLXIPL antibody; MONDOB antibody; WBS14_HUMAN antibody; WBSCR 14 antibody; WBSCR14 antibody; Williams Beuren syndrome chromosome region 14 antibody; Williams Beuren syndrome chromosome region 14 protein antibody; Williams-Beuren syndrome chromosomal region 14 protein antibody; WS basic helix loop helix leucine zipper protein antibody; WS basic-helix-loop-helix leucine zipper protein antibody; WS bHLH antibody; WS-bHLH antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MLXIPL
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.
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基因功能參考文獻：
- ChREBP regulates gene transcription related to glucose and lipid metabolism. Findings from knockout mice and human subjects suggest that ChREBP helps to induce hepatic steatosis, dyslipidemia, and glucose intolerance. [review] PMID: 27919710
- The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) with dyslipidemia in an Iranian population. PMID: 29858861
- Data (including data from studies using tissues/cells from transgenic mice) suggest that ChREBPalpha up-regulates expression and activity of NRF2, initiating mitochondrial biogenesis in beta-cells; induction of NRF2 is required for ChREBPalpha-mediated effects and for glucose-stimulated beta-cell proliferation. [NRF2 = nuclear factor (erythroid-derived 2)-like 2 protein] PMID: 29764859
- ChREBP was initially studied as a master regulator of lipogenesis in liver and fat tissue, it is now clear that ChREBP functions as a central metabolic coordinator in a variety of cell types in response to environmental and hormonal signals, with wide implications in health and disease. PMID: 28768172
- A nutrient-sensitive mTOR/ChREBP regulated transcriptional network could be a novel target to improve beta cell survival and glucose homeostasis in diabetes. PMID: 28606928
- these findings support a carbohydrate-mediated, ChREBP-driven mechanism that contributes to hepatic insulin resistance. PMID: 27669460
- results indicated that the age and total cholesterol concentrations were independent influential factors of ChREBP methylation and DNMT1 variants could probably influence LDL-C to further modify ChREBP DNA methylation PMID: 27281235
- p = 6.69 x 10(-9) ] on chr7 at the carbohydrate-responsive element-binding protein-encoding (MLXIPL) gene locus displayed significant protective characteristics, while another variant rs6982502 [0.76 (0.68-0.84); p = 5.31 x 10(-7) ] on chr8 showed similar but weaker properties. PMID: 27599772
- ChREBP role in non-alcoholic fatty liver disease.The involvement of ChREBP in FASN promoter histone modification. PMID: 28027934
- This cross-sectional study suggests that MLXIPL rs3812316 genotypes may be associated with Triglyceride levels. there were significantly different genotype distributions in two TG categories: (1) subjects with normal TG values had a significantly higher G allele frequency than those with elevated TG levels PMID: 27854512
- The results revealed the novel mechanism by which HNF-4alpha promoted ChREBP transcription in response to glucose, and also demonstrated that ChREBP-alpha and HNF-4alpha synergistically increased ChREBP-beta transcription. PMID: 27029511
- High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes. PMID: 27033449
- Diet-induced obesity increases basal expression of ChREBPbeta, which may increase the risk of developing hepatic steatosis, and fructose-induced activation is independent of gluconeogenesis. PMID: 26526060
- Data suggest that expression of ChREBPbeta isoform is up-regulated in pancreatic beta-cells in response to elevated levels of glucose (i.e., hyperglycemic conditions). PMID: 26384380
- Polymorphisms in lipid level modifier MLXIPL, GCKR, GALNT2, CILP2, ANGPTL3 and TRIB1 genes are highly associated with plasma lipid level changes. PMID: 25573592
- Single-nucleotide polymorphisms alleles near MLXIPL that were associated with higher coffee consumption. PMID: 25288136
- A major function of Mio in mitosis is to regulate the activation/deactivation of Plk1 and Aurora A. PMID: 26124292
- the single nucleotide polymorphism of MLXIPL is significantly associated with Non-alcoholic Fatty Liver Disease. PMID: 26177557
- results demonstrate that AGEs-RAGE signaling enhances cancer cell proliferation in which AGEs-mediated ChREBP induction plays an important role. PMID: 25111846
- Significant linkage disequilibria were noted among ZNF259, BUD13 and MLXIPL SNPs and serum lipid levels. PMID: 24989072
- demonstrates that Chrebp interacts with AR and regulates its transcriptional activity PMID: 24845031
- The MLXIPL-rs3812316 was associated with lower baseline triglycerides and lower hypertriglyceridemia. PMID: 24448738
- FLII is a component of the ChREBP transcriptional complex and negatively regulates ChREBP function in cancer cells. PMID: 24055811
- High glucose-induced, ChREBP-mediated, and normoxic HIF-1alpha activation that may be partially responsible for neovascularization in both diabetic and age-related retinopathy. PMID: 24664750
- The ChREBP mutant, W130A, did not exhibit HG-induced lipid accumulation and fibrotic proteins, suggesting that the Trp-130 residue in the MCR3 domain is important in the development of glomerulosclerosis. PMID: 24616092
- The ChREBP expression may be reflective of an aerobic metabolic phenotype that may conflict with hypoxia-induced signalling but provide a mechanism for growth at the oxygenated edge of the tumours. PMID: 24366300
- ChREBP plays a key role in reprogramming glucose and lipid metabolism in human cytomegalovirus infection. PMID: 24449882
- Data suggest that CHREBP is a central regulator of glycolysis/lipogenesis in liver and apoptosis/proliferation in specific cell types. [REVIEW] PMID: 23597489
- Data suggest that the activity of CHREBP is regulated via various mechanisms and that CHREBP is involved in the modulation of glucose and lipid metabolism in liver, pancreatic beta-cells, and adipose tissue. [REVIEW] PMID: 23604004
- Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes. PMID: 23530060
- de novo lipogenesis predicts metabolic health in humans in a tissue-specific manner and is likely regulated by glucose-dependent carbohydrate-responsive element-binding protein activation. PMID: 23443556
- Data from obese adolescents with prediabetes/early type 2 diabetes suggest that expression of ChREBP-alpha/beta in abdominal subcutaneous adipose tissue is inversely related to hyperglycemia severity and positively correlated to insulin resistance. PMID: 23209190
- ChREBP overexpression induced expression of stearoyl-CoA desaturase 1 (Scd1), the enzyme responsible for the conversion of saturated fatty acids (SFAs) into MUFAs PMID: 22546860
- The rs3812316 and the haplotypes in ChREBP gene appeared to be related to high susceptibility to CAD PMID: 21726544
- Multiple linear regression models based on 2373 individuals of Asian origin showed that the H allele of the MLXIPL gene was significantly associated with decreased concentrations of plasma triglycerides. PMID: 21938000
- ChREBP-beta expression in human adipose tissue predicts insulin sensitivity, indicating that it may be an effective target for treating diabetes. PMID: 22466288
- Our study reports that PP2A activity is dispensable for ChREBP activation in response to glucose and that dephosphorylation on Ser-196 is not sufficient to promote ChREBP nuclear translocation in the absence of a rise in glucose metabolism. PMID: 21835137
- an important mechanism by which importin-alpha and 14-3-3 control movement of ChREBP in and out of the nucleus in response to changes in glucose levels in liver PMID: 21665952
- sorcin retains ChREBP in the cytosol at low glucose concentrations and may act as a Ca(2+) sensor for glucose-induced nuclear translocation and the activation of ChREBP-dependent genes. PMID: 22338092
- The dramatic increase of ChREBP mRNA and protein levels during preadipocyte differentiation suggests a role in adipogenesis. PMID: 21840420
- ChREBP may function as a transcriptional repressor as well as an activator. PMID: 21811631
- in immortalized hepatocytes and in HepG2 hepatoma cells, only SREBP1c was able to induce adiponutrin/PNPLA3 expression, whereas ChREBP was unable to modulate its expression PMID: 21145868
- ChREBP is a critical and direct mediator of glucose repression of PPARalpha gene expression in pancreatic beta-cells PMID: 21282101
- These results suggest that the O-linked glycosylation of ChREBP itself or other proteins that regulate ChREBP is essential for the production of functional ChREBP. PMID: 21036147
- a new nuclear export signal site ("NES1") of ChREBP was reported. PMID: 20025850
- suppression of ChREBP led to a p53-dependent reduction in tumor growth. These results demonstrate that ChREBP plays a key role both in redirecting glucose metabolism to anabolic pathways and suppressing p53 activity PMID: 19995986
- we were not able to find any statistically significant association between the single nucleotide polymorphisms in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer PMID: 19252981
- This evolutionally conserved mechanism may play an essential role in glucose-responsive gene regulation. PMID: 16644671
- Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. PMID: 18193046
- Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity.( PMID: 18591247
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相關疾病：WBSCR14 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
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亞細胞定位：Nucleus.
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組織特異性：Expressed in liver, heart, kidney, cerebellum and intestinal tissues.
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數據庫鏈接：
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