MLST8 Antibody, HRP conjugated

說明書

中文名稱：

MLST8兔多克隆抗體, HRP偶聯(lián)
貨號(hào)：

CSB-PA863130LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MLST8 Polyclonal antibody
Uniprot No.：

Q9BVC4
基因名：

MLST8
別名：

G protein beta subunit like antibody; G protein beta subunit-like antibody; Gable antibody; GbetaL antibody; GBL antibody; GBL protein antibody; LST8 antibody; LST8_HUMAN antibody; Mammalian lethal with SEC13 protein 8 antibody; MGC111011 antibody; mLST8 antibody; MTOR associated protein LST8 homolog (S. cerevisiae) antibody; POP3 antibody; POP3 homolog (S. pombe) antibody; Protein GbetaL antibody; Target of rapamycin complex subunit LST8 antibody; TORC subunit LST8 antibody; WAT1 antibody; WAT1 homolog (S. pombe) antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Target of rapamycin complex subunit LST8 protein (159-220AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
基因功能參考文獻(xiàn)：
1. NEAT1 was potentially communicated with mTOR signaling target protein mLST8 via the association with miR-181b in type 2 diabetes mellitus. PMID: 28643459
2. Autophagy regulates c-MET phosphorylation via an mTORC2-dependent mechanism. PMID: 28475179
3. Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus. PMID: 26787466
4. MLST8 upregulation may contribute to tumor progression. PMID: 25906254
5. MLST8 polymorphism is associated with gastric cancer. PMID: 23423739
6. The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8. PMID: 23594158
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亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

WD repeat LST8 family
組織特異性：

Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 24825

OMIM: 612190

KEGG: hsa:64223

STRING: 9606.ENSP00000380313

UniGene: Hs.29203

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