MICAL1 Antibody, Biotin conjugated

說明書

中文名稱：

MICAL1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA851555LD01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MICAL1 Polyclonal antibody
Uniprot No.：

Q8TDZ2
基因名：

MICAL1
別名：

CasL interacting molecule antibody; DKFZp434B1517 antibody; FLJ11937 antibody; FLJ21739 antibody; MICA1_HUMAN antibody; MICAL 1 antibody; MICAL antibody; MICAL1 antibody; microtubule associated monoxygenase; calponin and LIM domain containing 1 antibody; Molecule interacting with CasL protein 1 antibody; NEDD9 interacting protein with calponin homology and LIM domains antibody; NEDD9-interacting protein with calponin homology and LIM domains antibody; NICAL antibody; OTTHUMP00000016969 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human [F-actin]-methionine sulfoxide oxidase MICAL1 protein (806-1067AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.
基因功能參考文獻：
1. Methionine oxidation is regulated in vivo by monooxygenases of the MICAL family. (Review) PMID: 28229915
2. describe methods to characterize MICAL-mediated F-actin disassembly using in vitro assays with purified proteins PMID: 27787846
3. The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion. PMID: 27430308
4. The MICAL1 directly induce oxidation of actin molecules, leading to actin depolymerization. ROS production by MICAL1 also causes oxidation of collapsin response mediator protein-2 which subsequently undergoes phosphorylation. PMID: 23834433
5. although MICAL1 is auto-inhibited by its C-terminal coiled-coil region, MICAL2 remains constitutively active and affects stress fibers, suggesting differential but complementary roles for MICAL1 and MICAL2 in actin microfilament regulation PMID: 22331357
6. Faint and scattered immunoreactivity for Mical-1 is observed in neurons of the neocortex of the temporal lobe epilepsy group, while strong immunoreactivity for Mical-1 is shown in control subjects. PMID: 21638339
7. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. PMID: 21730291
8. a CasL interacting molecule that associates with vimentin PMID: 11827972
9. MICAL-1 isoforms with their multidomain structure are novel rab1 interacting proteins that function as scaffold proteins connecting different components in the cell. PMID: 12788069
10. The unfolding of MICAL-1 calpolnin homology (CH) domain was studied. PMID: 17662518
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亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton. Midbody.
蛋白家族：

Mical family
組織特異性：

Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
數據庫鏈接：

HGNC: 20619

OMIM: 607129

KEGG: hsa:64780

STRING: 9606.ENSP00000351664

UniGene: Hs.33476

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