MFF Antibody, Biotin conjugated
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中文名稱：MFF兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA013751LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) MFF Polyclonal antibody
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Uniprot No.：
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基因名：MFF
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別名：C2orf33 antibody; Chromosome 2 open reading frame 33 antibody; DKFZp666J168 antibody; GL004 antibody; Mff antibody; MFF_HUMAN antibody; MGC110913 antibody; Mitochondrial fission factor antibody; OTTHUMP00000164235 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Mitochondrial fission factor protein (1-322AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
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基因功能參考文獻：
- Data show that increasing dynamin-related protein 1 (Drp1) SUMOylation by knocking down SUMO1-sentrin-SMT3 specific protease 3 (SENP3) reduces both Drp1 binding to mitochondrial fission factor protein (Mff) and stress-induced cytochrome c release. PMID: 28262828
- expressions of TIA-1 and MFF were augmented in the cancerous liver tissues compared to the corresponding non-tumor tissues at mRNA and protein level, while the levels of miR-200a-3p and miR-27a/b were relatively lower in the cancerous liver tissues PMID: 29496454
- We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations PMID: 26783368
- membrane-anchored Mff differentially regulates various Drp1 isoforms. PMID: 26578513
- Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC). PMID: 25912308
- loss of Mff results in failure of Parkin translocation and final clearance of damaged mitochondria PMID: 26008206
- Mitochondrial fission factor (MFF) mRNA is a direct target of miR-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region. PMID: 25431021
- TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. PMID: 23284813
- PEX11 proteins attract both Mff and human Fis1 (hFis1) to their site of action. PMID: 22595523
- MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS production, and the onset of autophagy and mitophagy. PMID: 22878233
- MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
- Mff is a novel component of a conserved membrane fission pathway used for constitutive and induced fission of mitochondria and peroxisomes. PMID: 18353969
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相關(guān)疾病：Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2)
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亞細胞定位：Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
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蛋白家族：Tango11 family
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組織特異性：Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
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數(shù)據(jù)庫鏈接：
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