MED26 Antibody

中文名稱：

MED26兔多克隆抗體
貨號：

CSB-PA013659LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA013659LA01HU diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MED26 Polyclonal antibody
Uniprot No.：

O95402
基因名：

MED26
別名：

Activator recruited cofactor 70 kDa component antibody; Activator-recruited cofactor 70 kDa component antibody; ARC 70 antibody; ARC70 antibody; Cofactor required for Sp1 transcriptional activation subunit 7 antibody; Cofactor required for Sp1 transcriptional activation, subunit 7 (70kD) antibody; Cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa antibody; CRSP 7 antibody; CRSP complex subunit 7 antibody; CRSP70 antibody; MED 26 antibody; Med26 antibody; MED26_HUMAN antibody; Mediator complex subunit 26 antibody; Mediator of RNA polymerase II transcription subunit 26 antibody; Transcriptional coactivator CRSP70 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Mediator of RNA polymerase II transcription subunit 26 protein (372-523AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MED26 Antibody (CSB-PA013659LA01HU)，的標記方式是Non-conjugated。對于MED26 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA013659LB01HU	MED26 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013659LC01HU	MED26 Antibody, FITC conjugated
Biotin	CSB-PA013659LD01HU	MED26 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
基因功能參考文獻：
1. EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain. PMID: 28893534
2. the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes PMID: 25575120
3. MED26 can function as a molecular switch that interacts first with TFIID in the Pol II initiation complex and then exchanges TFIID for complexes containing ELL/EAF and P-TEFb to facilitate transition of Pol II into the elongation stage of transcription. PMID: 21729782
4. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation PMID: 12050112
5. findings identify MED19/MED26 as a probable composite REST interface in Mediator and further clarify the mechanistic basis by which Mediator facilitates REST-imposed epigenetic restrictions on neuronal gene expression PMID: 19049968
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亞細胞定位：

Nucleus.
蛋白家族：

Mediator complex subunit 26 family
數據庫鏈接：

HGNC: 2376

OMIM: 605043

KEGG: hsa:9441

STRING: 9606.ENSP00000263390

UniGene: Hs.715040

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