The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA966451(MCMBP Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, 293T cells, Primary antibody: CSB-PA966451(MCMBP Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
基因功能參考文獻:
the MCMBP protein accumulates to high levels in cancer cells, whereas in normal proliferating tissue its abundance is low, indicating that MCMBP could be exploited as a novel diagnostic marker for this type of carcinoma. PMID: 25246271
Data indicate that MCM-BP binds USP7 on chromatin and can mediate an interaction between the USP7 and MCM proteins. PMID: 24190967
results suggest that MCM-BP makes multiple contributions to human cells that are not limited to unloading of the MCM complex PMID: 22250201
MCM-BP can decrease phosphorylation by DDK but is not a substrate. PMID: 22540012
MCM-BP silencing in human cells also delays MCM dissociation in late S phase PMID: 21196493
Knockdown of the human ETG1 results in defective chromatid cohesion. PMID: 20090939
MCM-BP is conserved in multicellular eukaryotes and shares limited homology with MCM proteins. MCM-BP formed a complex with MCM3 to MCM7, which excluded MCM2. PMID: 17296731
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亞細胞定位:
Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.