MBNL3 Antibody, FITC conjugated
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中文名稱：MBNL3兔多克隆抗體, FITC偶聯
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貨號：CSB-PA868322LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MBNL3 Polyclonal antibody
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Uniprot No.：
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基因名：MBNL3
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別名：A530038J18Rik antibody; AI661274 antibody; CHCR antibody; Cys3His CCG1 required protein antibody; Cys3His CCG1-required protein antibody; E430034C16Rik antibody; MBLX antibody; MBLX39 antibody; MBNL 3 antibody; Mbnl3 antibody; MBNL3_HUMAN antibody; MBXL antibody; Muscleblind like 3 antibody; Muscleblind like protein 3 antibody; Muscleblind like splicing regulator 3 antibody; Muscleblind like X linked protein antibody; Muscleblind-like protein 3 antibody; Muscleblind-like X-linked protein antibody; OTTMUSP00000019072 antibody; OTTMUSP00000019073 antibody; OTTMUSP00000019074 antibody; Protein HCHCR antibody; RP23-98P13.1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Muscleblind-like protein 3 protein (116-211AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
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基因功能參考文獻：
- The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing pacillin expression through the alternative splicing of lncRNA-PXN-AS1. PMID: 28553938
- results suggest that CHCR is an inhibitor of myogenesis PMID: 12297108
- MBNL proteins promote opposite splicing patterns for cardiac troponin T and insulin receptor alternative exons PMID: 15257297
- We exclude MBNL3 as the causative gene in this family. PMID: 17102799
- MBNL3 was not found in human samples. PMID: 19095965
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亞細胞定位：Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
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蛋白家族：Muscleblind family
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組織特異性：Highly expressed in the placenta.
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數據庫鏈接：
