MAT2A Antibody
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中文名稱：MAT2A兔多克隆抗體
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貨號：CSB-PA013517LA01HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA013517LA01HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA013517LA01HU at dilution of 1:100 -
Immunofluorescent analysis of PC-3 cells using CSB-PA013517LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) MAT2A Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：AdoMet synthase 2 antibody; AdoMet synthetase 2 antibody; AdoMet synthetase antibody; AMS 2 antibody; AMS2 antibody; MAT 2 antibody; MAT 2A antibody; MAT II antibody; MAT-II antibody; Mat2a antibody; MATA 2 antibody; MATA2 antibody; MATII antibody; Methionine adenosyltransferase 2 antibody; Methionine adenosyltransferase antibody; Methionine adenosyltransferase II alpha antibody; Methionine adenosyltransferase II antibody; METK2_HUMAN antibody; S adenosylmethionine synthetase gamma form antibody; S adenosylmethionine synthetase isoform type 2 antibody; S-adenosylmethionine synthase isoform type-2 antibody; SAMS 2 antibody; SAMS2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human S-adenosylmethionine synthase isoform type-2 protein (1-395AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產(chǎn)品，MAT2A Antibody (CSB-PA013517LA01HU)，的標記方式是Non-conjugated。對于MAT2A Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC, IF
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
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基因功能參考文獻：
- MAT2A expression is upregulated through mRNA stabilization upon SAM depletion. PMID: 29262316
- Increased MAT2A expression is associated with recurrence in hepatocellular carcinoma. PMID: 29448301
- High MAT2A expression is associated with tamoxifen-resistant breast cancer. PMID: 26418898
- METTL16 that controls MAT2A intron retention in response to intracellular SAM levels; splicing of the MAT2A retained intron is rapidly induced upon Met depletion, and this effect requires a conserved hairpin which is a METTL16 m6A substrate. PMID: 28525753
- methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. PMID: 27068473
- crystal structures of human MATalpha2 containing various bound ligands. PMID: 26858410
- acetylation decreased in hepatocellular cancer PMID: 25925782
- Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation. PMID: 25294683
- The data presented here support the conclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease. PMID: 25557781
- Results suggest that MAT2A is downregulated in cancer tissues of renal cell carcinomas patients and has function of tumor suppressor though repressing the expression of heme oxygenase-1. PMID: 24636201
- Differential gene expression of BACE1 and PSEN1 in the knockdown cells, which is possibly a consequence of MAT2A deregulation and may indicate a self regulatory mechanism. PMID: 22879628
- hypoxia-induced MAT2A expression is HIF-1alpha dependent PMID: 21460102
- Insulin-like growth factor 1 (IGF1) activates methionine adenosyltransferase 2A MAT2A) transcription by both known and novel pathways in colon cancer cells. PMID: 21406062
- X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production PMID: 21247894
- regulation of expression in hepatocarcinoma cells by L-methionine availability PMID: 12660248
- beta subunit associates with cirrhosis and cancer providing a proliferative advantage in hepatoma cells through its interaction with methionine adenosyltransferase II alpha2 and down-regulation of S-adenosylmethionine levels. PMID: 12671891
- up-regulation of MAT2A also provides a growth advantage and s-adenosylmethionine and methylthioadenosine can block mitogenic signaling in colon cancer cells PMID: 17631143
- Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells. PMID: 18041713
- This work was carried out to examine the role of MAT II activity and S-adenosylmethionine biosynthesis in the survival of leukemic T cells. PMID: 19048023
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蛋白家族：AdoMet synthase family
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組織特異性：Detected in kidney.
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數(shù)據(jù)庫鏈接：
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