MARCKSL1 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

P49006
基因名：

MARCKSL1
別名：

F52 antibody; Mac MARCKS antibody; Mac-MARCKS antibody; MacMARCKS antibody; Macrophage enriched Myristoylated Alanine Rich C Kinase Substrate Like Protein antibody; Macrophage myristoylated alanine-rich C kinase substrate antibody; MARCKS like 1 antibody; MARCKS like protein 1 antibody; MARCKS related protein antibody; MARCKS-like protein 1 antibody; MARCKS-related protein antibody; MARCKSL1 antibody; MLP antibody; MLP1 antibody; MRP antibody; MRP_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Human Marcksl1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
基因功能參考文獻(xiàn)：
1. MARCKSL1 showed potent anti-angiogenic activity and reduced the levels of VEGF and HIF-1alpha expression. MARCKSL1 decreased VEGFinduced phosphorylation of the PI3K/Akt signaling pathway components. PMID: 26555156
2. MARCKSL1 suppresses LOXL2-induced oncogenesis. PMID: 24863880
3. Patients with high expression of PPH3 and high MARCKSL1 protein had a lower survival rate versus patients with low MARCKSL1 and high PPH3 expression. PMID: 22772381
4. Gene knockdown in prostate cancer cells or in neurons reveals a critical role for MARCKSL1 in migration that is dependent on the phosphorylation state. PMID: 22751924
亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor.
蛋白家族：

MARCKS family
數(shù)據(jù)庫鏈接：

HGNC: 7142

OMIM: 602940

KEGG: hsa:65108

STRING: 9606.ENSP00000362638

UniGene: Hs.75061

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