MAP4 Antibody, Biotin conjugated

說明書

中文名稱：

MAP4兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA013435LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MAP4 Polyclonal antibody
Uniprot No.：

P27816
基因名：

MAP4
別名：

DKFZp779A1753 antibody; MAP-4 antibody; MAP4 antibody; MAP4_HUMAN antibody; MGC8617 antibody; Microtubule associated protein 4 antibody; Microtubule-associated protein 4 antibody; OTTHUMP00000210723 antibody; OTTHUMP00000210725 antibody; OTTHUMP00000210727 antibody; OTTHUMP00000210730 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Microtubule-associated protein 4 protein (575-818AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
基因功能參考文獻：
1. Expression level of MAP4 mRNA and protein in lung adenocarcinoma tissues were significantly higher than those in noncancerous tissues. MAP4 expression significantly correlated with tumor progression. PMID: 29743960
2. Microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses. PMID: 27911820
3. an intratumoral injection of MAP4-small interfering RNA (siRNA) remarkably inhibited the growth of the tumors that formed by the MAP4-expressing ESCC cells in nude mice, and a combination of MAP4-siRNA and Bevacizumab significantly enhanced the inhibition effect. Our data suggest that MAP4 is probably a useful prognostic biomarker and a potential therapeutic target for the disease. PMID: 26876215
4. MAP4 acts as a checkpoint molecule that balances positive and negative hallmarks of T cell activation. PMID: 28209780
5. Results show that marker rs218966 in gene PHF14 and rs9836027 in MAP4 significantly associated with hypertension; additionally, rare variants in SNUPN significantly associated with systolic blood pressure. PMID: 26866982
6. We demonstrated that the MAP4 (Ser696 and Ser787) phosphorylation increased concomitantly with the p38/MAPK pathway activation by the LPS and TNF-alpha stimulation of HPMECs, which induced MT disassembly followed by hyperpermeability. PMID: 25746230
7. Results demonstrated that MAP4 mutations contribute to the clinical spectrum of centrosomal defects and confirmed the complex role of a centrosomal protein in centrosomal, ciliary, and Golgi regulation associated with severe short stature. PMID: 25323976
8. Data show that cAMP/alpha isoform of the catalytic subunit of human PKA (PKAc-alpha) signaling can disrupt microtubule (MT) cytoskeleton by the phosphorylation of microtubule-Associated Protein 4 (MAP4). PMID: 24140250
9. MAP4, which is a binding partner of SEPT2. PMID: 23572511
10. there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization PMID: 22164227
11. DNAL1 and MAP4 may exert their functions in the HIV life cycle at reverse transcription, prior to nuclear translocation. PMID: 22018492
12. Data show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis. PMID: 21822276
13. Results suggest that structural features of the PJ domain of MAP4 may contribute to the formation of a radial array of microtubules in proliferating cells. PMID: 12079337
14. demonstrate that ectopic MAP4 promotes outgrowth of extended MTs during beta1-integrin-induced cell spreading PMID: 12123579
15. activity of MAP4 is downregulated by reduced free tubulin concentrations PMID: 12890753
16. adenovirus 2 E1B-55K protein blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters PMID: 14527689
17. MAP4 microtubule decoration interferes with beta-adrenergic receptor recycling and that this may be one mechanism for beta-adrenergic receptor downregulation in heart failure. PMID: 15528234
18. Truncation of the projection domain of MAP4 leads to attenuation of microtubule dynamic instability. PMID: 15840946
19. mAP4 interaction with septins modulates microtubule dynamics. PMID: 16093351
20. This first report of a genetic alteration involving MAP4 points to a potentially relevant target gene in diffuse large B-cell lymphoma. PMID: 16804917
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亞細胞定位：

Cytoplasm, cytoskeleton.
數據庫鏈接：

HGNC: 6862

OMIM: 157132

KEGG: hsa:4134

STRING: 9606.ENSP00000353375

UniGene: Hs.517949

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