MAP3K6 Antibody

說明書

產品詳情

Uniprot No.：

O95382
基因名：

MAP3K6
別名：

Apoptosis signal regulating kinase 2 antibody; Apoptosis signal-regulating kinase 2 antibody; ASK2 antibody; EC 2.7.11.25 antibody; M3K6_HUMAN antibody; MAP3K6 antibody; MAPKKK6 antibody; MEKK6 antibody; MGC125653 antibody; MGC20114 antibody; Mitogen-activated protein kinase kinase kinase 6 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human MEK Kinase-6.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:5000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.
基因功能參考文獻：
1. Data show that the MAPKKK6 ASK2, a modulator of MAPKKK5 ASK1 signaling, was essential for ASK1-dependent apoptosis, but not for inducing interferon-beta (IFNB) expression. PMID: 26243192
2. MAP3K6 acts as a tumor suppressor, and studies showing the presence of somatic mutations in MAP3K6 in non-hereditary gastric cancers and gastric cancer cell lines, point towards MAP3K6 variants as a predisposing factor for familial gastric cancer PMID: 25340522
3. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. PMID: 17210579
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
數據庫鏈接：

HGNC: 6858

OMIM: 604468

KEGG: hsa:9064

STRING: 9606.ENSP00000350195

UniGene: Hs.194694

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