MAGI2 Antibody

說明書

中文名稱：

MAGI2兔多克隆抗體
貨號：

CSB-PA213488
規格：

￥2024
圖片：
Western blot analysis of extracts from HT-29 cells, using MAGI2 antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MAGI2 Polyclonal antibody
Uniprot No.：

Q86UL8
基因名：

MAGI2
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from internal of Human MAGI2.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
基因功能參考文獻：
1. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. PMID: 29679339
2. MAGI-2 immunoreactivity is elevated in prostate cancer and high-grade prostatic intraepithelial neoplasia compared with normal tissue, suggesting that MAGI-2 may contribute to prostate carcinogenesis. PMID: 26980016
3. Immunohistochemistry in kidney sections from these patients revealed that mutations resulted in lack of or diminished podocyte MAGI2 expression. Our data support the finding that mutations in the MAGI2 gene are causal for congenital steroid-resistant nephrotic syndrome PMID: 27932480
4. MAGI-2 could represent a useful adjunct for diagnosis of prostatic adenocarcinoma PMID: 27543977
5. The expression of MAGI2 mRNA was significantly down-regulated in PC3, LNCaP and DU-145 PCa cell lines. PMID: 24985972
6. MAGI2, SERPINE2, and NT5C3B expression levels are associated with airway wall thickening and additionally with bronchial inflammation, emphysema, and lung function, respectively, all features of chronic obstructive pulmonary disease. PMID: 25517131
7. Data show that the miR-134/487b/655 cluster regulates TGF-beta1-induced epithelial-mesenchymal transition and affected the resistance to gefitinib by directly targeting membrane-associated guanylate kinase, WW, and PDZ domain-containing protein 2 (MAGI2). PMID: 24258346
8. In Usher syndrome 1G, mutations in SANS eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration. PMID: 24608321
9. MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. PMID: 23754155
10. Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. PMID: 22649501
11. Results presented herein provide further evidence for a role of MAGI2 in bipolar affective disorder and schizophrenia etiology. PMID: 22381734
12. Interstitial deletions that include the MAGI2 gene on chromosome 7q11.23-q.21.11 are associated with IS cases. PMID: 18565486
13. there was no association of MAGI2 and PARD3 with IBD. PMID: 21515326
14. analysis of 7q11.21-q11.23 and infantile spasms without deletion of MAGI2 [case report] PMID: 20101691
15. Data show that AIP1 is a novel GTPase-activating protein for Arf6, a small GTPase regulating cellular PIP(2) production and formation of the TLR4-TIRAP-MyD88 complex. PMID: 19948740
16. PTEN plays a critical role in MAGI-2-induced inhibition of cell migration and proliferation in human hepatocarcinoma cells PMID: 17880912
17. MAGI2 genetic variation is associated with inflammatory bowel disease. PMID: 18720471
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相關疾病：

Nephrotic syndrome 15 (NPHS15)
亞細胞定位：

Cytoplasm. Late endosome. Cell junction, synapse, synaptosome. Cell membrane; Peripheral membrane protein.
蛋白家族：

MAGUK family
組織特異性：

Specifically expressed in brain.
數據庫鏈接：

HGNC: 18957

OMIM: 606382

KEGG: hsa:9863

STRING: 9606.ENSP00000346151

UniGene: Hs.603842

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