MAGEB2 Antibody

說明書

產品詳情

Uniprot No.：

O15479
基因名：

MAGEB2
別名：

MAGEB2Melanoma-associated antigen B2 antibody; Cancer/testis antigen 3.2 antibody; CT3.2 antibody; DSS-AHC critical interval MAGE superfamily 6 antibody; DAM6 antibody; MAGE XP-2 antigen antibody; MAGE-B2 antigen antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Human MAGEB2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
基因功能參考文獻：
1. MAGEB2 can be aberrantly demethylated and expressed in malignant peripheral nerve sheath tumors. Conversely, the gene may not be demethylated in any types of neurofibroma, suggesting that the demethylation does not occur before malignant transformation. PMID: 26642794
2. MageB2 counteracts E2F inhibition by ribosomal proteins independently of Mdm2 expression PMID: 26468294
3. we identified MAGEB2 as activated by promoter demethylation in HNSCCand demonstrates growth promoting effects in a minimally transformed oral keratinocyte cell line. PMID: 23029077
4. Valproic acid causes a change in acetylation of this gene. PMID: 17012225
組織特異性：

Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.
數據庫鏈接：

HGNC: 6809

OMIM: 300098

KEGG: hsa:4113

STRING: 9606.ENSP00000368273

UniGene: Hs.113824

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