LZTFL1 Antibody, FITC conjugated

說明書

中文名稱：

LZTFL1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA885687LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LZTFL1 Polyclonal antibody
Uniprot No.：

Q9NQ48
基因名：

LZTFL1
別名：

5530402H04Rik antibody; 6130400H19Rik antibody; AI414725 antibody; AW048545 antibody; BBS17 antibody; DKFZp686H2076 antibody; FLJ36386 antibody; Leucine zipper transcription factor like 1 antibody; Leucine zipper transcription factor like protein 1 antibody; Leucine zipper transcription factor-like protein 1 antibody; LZTFL 1 antibody; Lztfl1 antibody; Lztfl1 leucine zipper transcription factor-like 1 antibody; LZTL1_HUMAN antibody; MGC106871 antibody; MGC108960 antibody; Putative uncharacterized protein DKFZp686H2076 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Leucine zipper transcription factor-like protein 1 protein (116-299AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
基因功能參考文獻：
1. LZTFL1 inhibits lung tumorigenesis PMID: 26364604
2. these data indicate that LZTFL1 modulates T cell activation and IL-5 levels. PMID: 26700766
3. LZTFL1 binds beta-catenin in the cytoplasm of the cell and inhibited its nuclear translocation PMID: 25005785
4. This special subtype of polydactyly in BBS patients is easily identified on clinical examination and prompts for priority sequencing of LZTFL1 (BBS17). PMID: 23692385
5. The absence of LZTFL1 leads to a BBS phenotype with enhanced developmental abnormalities associated with cellular Shh dysfunction. LZTFL1 is a novel BBS gene (BBS17). PMID: 22510444
6. Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling PMID: 22072986
7. LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation. PMID: 20233871
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相關疾?。?/div>
Bardet-Biedl syndrome 17 (BBS17)
亞細胞定位：

Cytoplasm.
蛋白家族：

LZTFL1 family
組織特異性：

Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, splee
數據庫鏈接：

HGNC: 6741

OMIM: 606568

KEGG: hsa:54585

STRING: 9606.ENSP00000296135

UniGene: Hs.30824

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