LPIN2 Antibody
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中文名稱：LPIN2兔多克隆抗體
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貨號：CSB-PA013063GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：LPIN2
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別名：KIAA0249 antibody; Lipin-2 antibody; Lipin2 antibody; LPIN 2 antibody; LPIN2 antibody; LPIN2_HUMAN antibody; OTTHUMP00000162242 antibody; Phosphatidate phosphatase LPIN2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Human LPIN2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
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基因功能參考文獻：
- Structural variants unique to the malignant cell line inactivated: LPIN2, a phosphatidic acid phosphatase and a co-factor of PGC1a that is important for lipid metabolism and for suppressing autoinflammation. PMID: 23792589
- We describe two brothers with Majeed syndrome, homozygous novel 2-base pair deletion in LPIN2 (c.1312_1313delCT; p.Leu438fs+16X) PMID: 23087183
- LPIN1-related myolysis constitutes a major cause of early-onset rhabdomyolysis and occasionally in adults. Heterozygous LPIN1 mutations may cause mild muscular symptoms. No major defects of LPIN2 or LPIN3 genes were associated with muscle manifestations. PMID: 22481384
- role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages PMID: 22334674
- Data revealed that lipin 1 formed stable homo-oligomers with itself and hetero-oligomers with lipin 2/3. PMID: 20735359
- LPIN2 gene was excluded as a candidate for myopia 2 (MYP2), but the SNPs detected in this study will aid in future mapping and association studies involving this gene. PMID: 15862761
- We conclude that homozygous mutations in LPIN2 result in Majeed syndrome. Understanding the aberrant immune response in this condition will shed light on the aetiology of other inflammatory disorders of multifactorial aetiology PMID: 15994876
- A single nucleotide polymorphism of the LPIN2 gene is associated with type 2 diabetes and fat distribution. PMID: 17804763
- distinct and non-redundant functions of lipin 1 and 2 regulate lipid production during the cell cycle and adipocyte differentiation PMID: 18694939
- lipin 2 plays an important role as a hepatic PAP-1 enzyme. PMID: 19136718
- A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. PMID: 19717560
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相關疾病：Majeed syndrome (MJDS)
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亞細胞定位：Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane.
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蛋白家族：Lipin family
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組織特異性：Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
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數據庫鏈接：
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