LNX1 Antibody, Biotin conjugated

說明書

中文名稱：

LNX1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA848393LD01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LNX1 Polyclonal antibody
Uniprot No.：

Q8TBB1
基因名：

LNX1
別名：

LNX1 antibody; LNX antibody; PDZRN2 antibody; UNQ574/PRO1136 antibody; E3 ubiquitin-protein ligase LNX antibody; EC 2.3.2.27 antibody; Ligand of Numb-protein X 1 antibody; Numb-binding protein 1 antibody; PDZ domain-containing RING finger protein 2 antibody; RING-type E3 ubiquitin transferase LNX antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase LNX protein (133-259AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
基因功能參考文獻：
1. study provided the evidences that LNX1 signaling plays important roles in regulating the stemness of colon cancer cells PMID: 29190716
2. LNX was closely related to human gliomas and suggested it plays an important role in gliomas by notch signaling. PMID: 16324299
3. LNX1-mediated ubiquitination and degradation of PBK inhibited cell proliferation and enhanced sensitivity to doxorubicin-induced apoptosis. PMID: 22889411
4. identify and confirm six novel LNX1 binding partners: KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2 and PBK, and suggest that LNX1 functions as a signalling scaffold. PMID: 22087225
5. The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever. PMID: 22066909
6. LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis PMID: 22045731
7. Down-regulation of LNX could result in cell cycle arrest in G0/G1 phase through inhibition of beta-catenin, MAPK, NFkappaB, c-Myc-dependent pathway and activation of p53, TGF-beta-dependent pathway. PMID: 21104141
8. LNX and RhoC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1. PMID: 19701800
9. identifed ligand of Numb protein X as an Np9-interacting partner; findings point to the possibility that Np9 affects tumorigenesis through the LNX/Numb/Notch pathway PMID: 15367597
10. The presence of multiple protein binding domains involved in signal transduction and interaction with Numb and SKIP suggested an important role for LNX in tumorogenesis. PMID: 16002321
11. The interaction of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src. PMID: 17936276
12. Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas. PMID: 18940473
13. A direct interaction between ErbB2 and mouse LNX1 was identified, suggesting that LNX1 may be involved in neuregulin-1/ErbB signaling in perisynaptic Schwann cells. PMID: 16122940
14. The tyrosine phosphorylation of the LDNPAY sequence motif in mouse LNX could generate a binding site for the phosphorylation-dependent binding of other PTB domain-containing proteins. PMID: 9535908
15. Describes various glioblastoma multiforms containing the amplicon on chromosomal segment 4q12, including the LNX1 gene. PMID: 17504929
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亞細胞定位：

Cytoplasm.
組織特異性：

Expressed in heart, placenta, kidney, pancreas and brain.
數據庫鏈接：

HGNC: 6657

OMIM: 609732

KEGG: hsa:84708

STRING: 9606.ENSP00000263925

UniGene: Hs.518760

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