LIN9 Antibody
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中文名稱(chēng)：LIN9兔多克隆抗體
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貨號(hào)：CSB-PA716370LA01HU
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規(guī)格：￥440
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圖片：
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IHC image of CSB-PA716370LA01HU diluted at 1:800 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱(chēng)：Rabbit anti-Homo sapiens (Human) LIN9 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：BARA antibody; Beta subunit-associated regulator of apoptosis antibody; Beta-subunit associated regulator of apoptosis antibody; hLin-9 antibody; huLin-9 antibody; lin-9 antibody; lin9 antibody; LIN9_HUMAN antibody; pRB-associated protein antibody; Protein lin-9 homolog antibody; TGS antibody; TUDOR gene similar protein antibody; Type I interferon receptor beta chain-associated protein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Protein lin-9 homolog protein (5-103AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁(yè)面中的產(chǎn)品，LIN9 Antibody (CSB-PA716370LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于LIN9 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：
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克隆類(lèi)型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:500-1:1000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.
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基因功能參考文獻(xiàn)：
- High LIN9 expression is associated with Triple-negative breast cancers. PMID: 28807940
- The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in breast cancer cells. PMID: 28061449
- LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression. PMID: 24475316
- Results show that E7 interacts with the B-Myb, FoxM1 and LIN9 components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters. PMID: 24141769
- Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms. PMID: 23381944
- inactivation of LIN9, a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen PMID: 21860417
- Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20360844
- Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
- Human Lin-9 has tumor-suppressing activities and the ability of hLin-9 to inhibit transformation is mediated through its association with pRB. PMID: 15538385
- Mutation of BARA/LIN-9 restores the expression of E2F target genes. PMID: 16730350
- Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1 PMID: 17098733
- human LIN-9, together with B-MYB, has a critical role in the activation of genes that are essential for progression into mitosis PMID: 17159899
- The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction. PMID: 17563750
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亞細(xì)胞定位：Nucleus, nucleoplasm. Note=Found in perinucleolar structures. Associated with chromatin.
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蛋白家族：Lin-9 family
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組織特異性：Expressed in thymus and testis.
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數(shù)據(jù)庫(kù)鏈接：
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