LIN7A Antibody

中文名稱：

LIN7A兔多克隆抗體
貨號：

CSB-PA012963LA01HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: LIN7A antibody at 6µg/ml
Lane 1: Human placenta tissue
Lane 2: Mouse kidney tissue
Lane 3: Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 26 kDa
Observed band size: 26 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) LIN7A Polyclonal antibody
Uniprot No.：

O14910
基因名：

LIN7A
別名：

hLin-7 antibody; Lin 7 homolog A (C. elegans) antibody; LIN 7A antibody; Lin-7A antibody; LIN7 antibody; LIN7A antibody; LIN7A_HUMAN antibody; MALS-1 antibody; Mammalian LIN 7 1 antibody; Mammalian lin-seven protein 1 antibody; Protein lin-7 homolog A antibody; Tax interaction protein 33 antibody; TIP-33 antibody; Veli-1 antibody; VELI1 antibody; Vertebrate lin-7 homolog 1 antibody; Vertebrate LIN7 homolog 1 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Protein lin-7 homolog A protein (1-233AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，LIN7A Antibody (CSB-PA012963LA01HU)，的標記方式是Non-conjugated。對于LIN7A Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA012963LB01HU	LIN7A Antibody, HRP conjugated	ELISA
FITC	CSB-PA012963LC01HU	LIN7A Antibody, FITC conjugated
Biotin	CSB-PA012963LD01HU	LIN7A Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
基因功能參考文獻：
1. Overexpression of LIN7 or IRSp53 did not prevent the formation of hyperfused mitochondria in cells coexpressing the Drp1 K38A mutant, thus suggesting that LIN7-IRSp53 complex requires functional Drp1 to regulate mitochondrial morphology. PMID: 27320196
2. This study therefore shows that LIN7A has a crucial role in the polarity abnormalities associated with breast carcinogenesis. PMID: 26887652
3. LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome. PMID: 24658322
4. LIN7A is a PDZ protein that interacts with human papillomavirus-16 E6 and forms a tripartite complex with MPP7 and DLG1, regulating the stability and localization of DLG1 to cell junctions. PMID: 17237226
5. Allelic and haplotype association was found between both BDNF and adult ADHD, and LIN-7 and adult ADHD. PMID: 18286632
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亞細胞定位：

Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction.
蛋白家族：

Lin-7 family
組織特異性：

Expressed in brain, testis, kidney, placenta and liver.
數(shù)據(jù)庫鏈接：

HGNC: 17787

OMIM: 603380

KEGG: hsa:8825

STRING: 9606.ENSP00000447488

UniGene: Hs.144333

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