LASP1 Antibody, FITC conjugated
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中文名稱：LASP1兔多克隆抗體, FITC偶聯
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貨號：CSB-PA04629C0Rb
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) LASP1 Polyclonal antibody
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Uniprot No.：
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基因名：LASP1
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別名：LASP 1 antibody; LASP-1 antibody; LASP1 antibody; LASP1_HUMAN antibody; LIM and SH3 domain protein 1 antibody; LIM and SH3 protein 1 antibody; Metastatic lymph node gene 50 protein antibody; MLN 50 antibody; MLN50 antibody; OTTHUMP00000164238 antibody; OTTHUMP00000164239 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human LIM and SH3 domain protein 1 protein (128-252AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
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基因功能參考文獻：
- Data shows that LASP1 is significantly upregulated in breast cancer tissues and cell lines, and its upregulation significantly associated with disease progression. Also, LASP1 was identified as a target gene of miR-133a, and its expression negatively regulated by miR-133a in breast cancer cells. PMID: 29207145
- An in vitro study showed that overexpression of miR-133b inhibited the proliferation, migration, and invasion of HepG2 and Hep3B cells. Similarly, knockdown of LASP1 reduced HepG2 and Hep3B cell proliferation, migration, and invasion. PMID: 28117027
- Findings indicated that LASP-1, as a downstream target of SOX9, may act as a novel biomarker for lung cancer and plays an important role in cell proliferation, migration, and invasion. PMID: 29138807
- miR-203a-3p suppresses tumor growth and metastasis through targeting LASP1 in NPC. PMID: 28982387
- LASP1 silencing elicited effects similar to miR-326 overexpression on HCC cells. PMID: 28713953
- A combination of low 14-3-3sigma and high LASP1 expression shows a worse trend with overall survival of colorectal cancer patients. PMID: 27156963
- Furthermore, we identify flotillin-1 (FLOT1) and histone H1 as downstream factors for cytoplasmic and nuclear pathway of S100A11, which are required for LASP1-S100A11 axis-mediated epithelial-mesenchymal transition and colorectal cancer progression. PMID: 27181092
- Overexpression of LASP-1 in thyroid cancer tissues.LASP-1 role in thyroid cancer cell proliferation and invasion.LASP-1 is an oncogene. PMID: 27938497
- Study found LASP1 to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown in esophageal squamous cell carcinoma. PMID: 28404954
- Data indicate that LIM and SH3 protein 1 (LASP1) is a direct target of miR-145. PMID: 27626692
- LASP1 enhances the expression and secretion of MMPs, favoring breast cancer cell migration and invasiveness. PMID: 27588391
- miR-218 contributes to PE by targeting LASP1 to inhibit trophoblast invasion PMID: 28412444
- The correlation between LIM and SH3 domain-containing protein expression levels in cancer and the poor outcome and metastatic behavior of tumors denotes the clinical significance of this protein and hints its potential value as a new cancer prognostic or even diagnostic biomarker PMID: 28621232
- LASP-1 contributes to the formation and progression of prostate cancer through a NF-kappaappa B pathway. PMID: 27840958
- High expression of miR218 is associated with gastric cancer. PMID: 27696291
- LASP-1 may essentially involve in the metastasis and growth of CCA and clinical significance of LASP-1 may reside in function as a biomarker to predict prognosis and as a promising therapeutic strategy for CCA patients by the inhibition of LASP-1 expression PMID: 26729195
- It is a target gene of miR-1. PMID: 26414725
- LASP-1 associated with UHRF1, G9a, Snail1 and di- and tri-methylated histoneH3 in a CXCL12-dependent manner based on immunoprecipitation and proximity ligation assays PMID: 25982273
- LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway. PMID: 26797416
- LASP-1, mediated by miR-203, has crucial functions in the proliferation, migration and invasion of human non-small cell lung cancer PMID: 26683818
- Detecting an affection of migratory processes after LASP-1 silencing, we propose that LASP-1 could impact on metastasis of CC [choriocarcinoma]cells. PMID: 26232936
- Results identified LASP1 as a hitherto unknown protein in melanocytes and as novel partner of dynamin in the physiological process of membrane constriction and melanosome vesicle release. PMID: 26061439
- Our results suggest that LASP-1 mRNA overexpression may be mainly implicated in female hepatocellular carcinoma (HCC) and cirrhotic HCCs; and that LASP1 may play its role with vimentin in HCC cells. PMID: 25760690
- LASP-1 overexpression was associated with aggressive phenotype in clear cell renal cell cancer. PMID: 24955835
- LASP1 plays key roles in cell structure, physiological processes, and cell signaling; overexpression contributes to cancer aggressiveness [review] PMID: 25622104
- LIM and SH3 protein 1 induces TGFbeta-mediated epithelial-mesenchymal transition in human colorectal cancer by regulating S100A4 expression. PMID: 25252758
- Study revealed that LASP1 phosphorylation results in an association with CRKL - another specific BCR-ABL substrate and bona fide biomarker for BCR-ABL activity. PMID: 24913448
- Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC. PMID: 25385028
- LASP-1, overexpressed in gastric cancer and associated with poor prognosis, plays an important role in the growth and metastasis of gastric cancer. PMID: 24990592
- Results show significant upregulation of LASP1 and SCAD protein levels in acute psychotic bipolar disorder samples. PMID: 24554194
- LASP1 was a direct target of miR-218 in prostate cells. PMID: 24815849
- LASP-1 is linked closely to tumourigenicity in oral cancer. PMID: 24386158
- Data indicate decreased cell migratory potential accompanied by enhanced cell adhesion, but no significant inhibition of cell proliferation as measured by in T24 cells upon LIM and SH3 (LASP)-1 protein (LASP-1) knockdown. PMID: 22481019
- LASP1 may play an important role in the pathogenesis of esophageal squamous cell carcinoma. PMID: 23254782
- Data show that miR-133a can target the 3' untranslated region (3'UTR) of LIM and SH3 protein 1 (LASP1) mRNA and suppress the expression of LASP1. PMID: 23968734
- Phosphorylation of LASP-1 by PKA at serine 146 induces translocation of the LASP-1/ZO-2 complex from the cytoplasm to the nucleus. PMID: 22665060
- A single-nucleotide polymorphism in the LASP1 gene promoter region is associated with schizophrenia susceptibility. PMID: 23040864
- High cytosolic LASP-1 expression is associated with hepatocellular carcinoma. PMID: 23084841
- miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1. PMID: 22940702
- Up-regulated of BIRC5 and LASP1 was able to abrogate the effects induced by transfection with the miR-203 precursor in triple negative breast cancer. PMID: 22713668
- These results demonstrated that hepatitis B virus X protein could upregulate LASP-1 through PI3-K pathway to promote the proliferation and migration of hepatoma cells. PMID: 22897902
- Data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in bladder cancer (BC). PMID: 20843712
- Data indicate that Lasp-1 is a novel component of podosomes and is involved in the regulation of podosomal function. PMID: 22514729
- LASP-1 has an essential role in growth and migration of ovarian carcinoma cells, possibly by influencing the localization of zyxin. PMID: 17211471
- LASP-1 gene expression enhances proliferation of colorectal cancer cells and may serve as a useful marker for colorectal cancer progression. PMID: 21215099
- LASP-1 interaction with CXCR2 is critical for CXCR2-mediated chemotaxis PMID: 20419088
- LASP1 knockdown by small interfering RNA-mediated silencing indicates its funcion role in progression and metastasis of medulloblastoma. PMID: 20924110
- LASP-1, S100A9 and RhoGDI were detected by proteomic analysis to be differentially expressed between normal mucosa, non-metastatic colorectal carcinoma and metastatic CRC tissue PMID: 20812987
- Overexpression of LASP-1 was found in metastatic colorectal cancer (CRC) tissues (p=0.002), and its expression level was closely correlated with overall survival of patients with CRC (p=0.002). PMID: 20660701
- Nuclear LASP-1-positivity may serve as a negative prognostic indicator for long-term survival of breast cancer patients. PMID: 20461080
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亞細胞定位：Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
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