LAS1L Antibody
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中文名稱：LAS1L兔多克隆抗體
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貨號：CSB-PA897285LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: 293 whole cell lysate
All lanes: LAS1L antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 84, 82, 77, 34 kDa
Observed band size: 84 kDa -
Immunofluorescence staining of HepG2 cells with CSB-PA897285LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) LAS1L Polyclonal antibody
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Uniprot No.：
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基因名：LAS1L
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別名：dJ475B7.2 antibody; FLJ12525 antibody; FLJ30133 antibody; FLJ45274 antibody; LAS1 like (S. cerevisiae) antibody; Las1 like antibody; LAS1L antibody; LAS1L_HUMAN antibody; Protein LAS1 homolog antibody; Ribosomal biogenesis protein LAS1L antibody; RP3 475B7.2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Ribosomal biogenesis protein LAS1L protein (490-565AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，LAS1L Antibody (CSB-PA897285LA01HU)，的標記方式是Non-conjugated。對于LAS1L Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IF 1:200-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
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基因功能參考文獻：
- LAS1L interacts with PELP1, TEX10, and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit. PMID: 22190735
- Analysis of high-molecular-weight RNAs confirmed that Las1L is required for ITS2 processing,which separates the 5.8S and 25S/28S rRNAs, as 32S was found to accumulate and 12S to diminish upon Las1L depletion. PMID: 22083961
- Data demonstrate that Las1L is essential for cell proliferation and biogenesis of the 60S ribosomal subunit. PMID: 20647540
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相關疾病：Wilson-Turner X-linked mental retardation syndrome (WTS)
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亞細胞定位：Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm.
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蛋白家族：LAS1 family
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數據庫鏈接：
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