KIRREL2 Antibody, HRP conjugated

說明書

中文名稱：

KIRREL2兔多克隆抗體, HRP偶聯
貨號：

CSB-PA754407LB01HU
規格：

￥880
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KIRREL2 Polyclonal antibody
Uniprot No.：

Q6UWL6
基因名：

KIRREL2
別名：

FILTRIN antibody; Kin of IRRE like 2 (Drosophila) antibody; Kin of IRRE-like protein 2 antibody; Kin of irregular chiasm like 2 antibody; Kin of irregular chiasm-like protein 2 antibody; KIRR2_HUMAN antibody; KIRREL2 antibody; NEPH3 antibody; Nephrin like 3 antibody; nephrin-like gene 1 antibody; Nephrin-like protein 3 antibody; NLG1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Kin of IRRE-like protein 2 protein (21-219AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May regulate basal insulin secretion.
基因功能參考文獻：
1. SNP V353M confers high risk of renal failure in primary hematuric glomerulopathies and predisposition to microalbuminuria in the general population PMID: 28334007
2. summarize the current knowledge of the functions of nephrin and Neph-family proteins and transcription factors and agents that control nephrin and Neph3 gene expression. PMID: 24219158
3. Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-kappaB and silenced by DNA methylation. PMID: 21980157
4. Identification of Filtrin as a member of nephrin-like proteins. PMID: 12504092
5. KIRREL2 protein is a beta-cell-expressed Ig domain protein and may be involved in pancreas development or beta cell function PMID: 12837264
6. Filtrin can act as autoantigen, and autoantibodies against these can be detected in patients with type 1 diabetes. PMID: 16741999
7. NF-kappaB and Sp1 response elements are essential for the basal transcriptional activity of the Neph3 promoter. PMID: 19703278
8. Filtrin is a novel protein with substantial homology to nephrin. It is a transmembrane protein of the immunoglobulin superfamily (apparent molecular weight 107 kDa) and most prominently expressed in the pancreas, lymph nodes as well as kidney glomerulus. PMID: 12504092
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Immunoglobulin superfamily
組織特異性：

Highly expressed in beta-cells of the pancreatic islets.
數據庫鏈接：

HGNC: 18816

OMIM: 607762

KEGG: hsa:84063

STRING: 9606.ENSP00000353331

UniGene: Hs.145729

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