KIF24 Antibody, Biotin conjugated

說明書

中文名稱：

KIF24兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA716354LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KIF24 Polyclonal antibody
Uniprot No.：

Q5T7B8
基因名：

KIF24
別名：

bA571F15.4 antibody; C9orf48 antibody; Kif24 antibody; KIF24_HUMAN antibody; kinesin family member 24 antibody; Kinesin-like protein KIF24 antibody; RP11-571F15.7 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Kinesin-like protein KIF24 protein (1168-1368AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle.
基因功能參考文獻：
1. Kif24 is a physiological substrate of Nek2, which regulates cilia disassembly through a concerted mechanism involving Kif24-mediated microtubule depolymerization. PMID: 26290419
2. Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly. PMID: 21620453
3. KIF24 rs17350674 polymorphism likely acts as a risk factor for sporadic Lobar Degeneration PMID: 20670673
4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20670673
亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
數據庫鏈接：

HGNC: 19916

OMIM: 613747

KEGG: hsa:347240

STRING: 9606.ENSP00000368464

UniGene: Hs.710246

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