KIF17 Antibody

中文名稱：

KIF17兔多克隆抗體
貨號：

CSB-PA865208LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human glioma using CSB-PA865208LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA865208LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA865208LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KIF17 Polyclonal antibody
Uniprot No.：

Q9P2E2
基因名：

KIF17
別名：

KIAA1405 antibody; KIF 17 antibody; KIF 17B antibody; KIF 3 related motor protein antibody; KIF 3X antibody; KIF17 antibody; KIF17_HUMAN antibody; KIF17B antibody; KIF3 related motor protein antibody; KIF3-related motor protein antibody; KIF3X antibody; Kinesin family member 17 antibody; Kinesin like protein KIF 17 antibody; Kinesin like protein KIF17 antibody; Kinesin-like protein KIF17 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Kinesin-like protein KIF17 protein (500-777AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，KIF17 Antibody (CSB-PA865208LA01HU)，的標記方式是Non-conjugated。對于KIF17 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA865208LB01HU	KIF17 Antibody, HRP conjugated	ELISA
FITC	CSB-PA865208LC01HU	KIF17 Antibody, FITC conjugated
Biotin	CSB-PA865208LD01HU	KIF17 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
基因功能參考文獻：
1. The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport. PMID: 28761002
2. In mammalian cells, KIF17 is dispensable for ciliogenesis and IFT-B trafficking but requires IFT-B, as well as its NLS, for its ciliary entry across the permeability barrier located at the ciliary base. PMID: 28077622
3. The first evidence of an interaction between septins and a nonmitotic kinesin is provided and it is suggested that SEPT9 modulates the interactions of KIF17 with membrane cargo. PMID: 26823018
4. KIF17 can modify RhoA-GTPase signaling to influence junctional actin and the stability of the apical junctional complex of epithelial cells. PMID: 26759174
5. Expression of KIF17 in schizophrenic postmortem brains was significantly lower than controls. Both genotypic distribution and allelic frequency of rs2296225 polymorphism were significantly different between the chronic schizophrenia subjects and controls. PMID: 26421900
6. although EB1 and KIF17-Tail may coordinate KIF17 catalytic activity, our data reveal a novel and direct role for KIF17 in regulating MT dynamics. PMID: 24072717
7. This study suggested that disruption of KIF17, although rare, could result in a schizophrenia phenotype and emphasize the possible involvement of rare de novo mutations in this disorder. PMID: 20646681
8. Depletion of KIF17 from cells growing in three-dimensional matrices results in aberrant epithelial cysts that fail to generate a single central lumen and to polarize apical markers. PMID: 20696710
9. Data show that the homodimeric kinesin-2 motor KIF17 is kept in an inactive state in the absence of cargo, and define two molecular mechanisms that contribute to autoinhibition of KIF17. PMID: 20530208
10. The intense placental expression of KIFC1 in syncytiotrophoblast and KIF17 in vascular endothelium suggests that both proteins might be important in a cargo-transport system. KIFC1 and KIF17 expression are increased of both in preeclamptia and diabetes. PMID: 19679349
11. KIF17b serves as a molecular motor component of a TB-RBP-mouse ribonucleoprotein complex transporting a group of specific CREM-regulated mRNAs. PMID: 14673085
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亞細胞定位：

Cytoplasm, cytoskeleton. Cell projection, cilium. Cell projection, dendrite.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
數據庫鏈接：

HGNC: 19167

OMIM: 605037

KEGG: hsa:57576

STRING: 9606.ENSP00000247986

UniGene: Hs.130411

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