KIF15 Antibody, HRP conjugated
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中文名稱(chēng)：KIF15兔多克隆抗體, HRP偶聯(lián)
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貨號(hào)：CSB-PA868310LB01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱(chēng)：Rabbit anti-Homo sapiens (Human) KIF15 Polyclonal antibody
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Uniprot No.：
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基因名：KIF15
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別名：KIF15 antibody; KLP2 antibody; KNSL7Kinesin-like protein KIF15 antibody; Kinesin-like protein 2 antibody; hKLP2 antibody; Kinesin-like protein 7 antibody; Serologically defined breast cancer antigen NY-BR-62 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Kinesin-like protein KIF15 protein (1-129AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：HRP
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克隆類(lèi)型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.
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基因功能參考文獻(xiàn)：
- KIF15 knockdown using short hairpin RNA in two human lung adenocarcinoma cell lines induced G1/S phase cell cycle arrest and inhibited cell growth. PMID: 30439711
- The non-motor microtubule-binding tail domain interacts with the microtubule's E-hook tail with a rupture force higher than the stall force of the motor. This allows Kif15 dimers to productively and efficiently generate forces that could potentially slide microtubules apart. PMID: 28918951
- Both Kif15 and KBP are required for the alignment of all the chromosomes to the metaphase plate and the assembly of stable kinetochore fibers of the correct length. PMID: 28445502
- This study identified KIF15 as a critical regulator that promotes pancreatic cancer proliferation, broadening our understanding of KIF15 function in tumorigenesis. PMID: 28595260
- To our knowledge, KIF15 is the first kinesin to be associated with congenital thrombocytopenia. PMID: 28150392
- KIF15 is involved in alternative spindle assembly pathways. PMID: 27091450
- When intersecting microtubules are parallel, Kif15 motors can drive (biased) parallel sliding because the motor simultaneously steps on both microtubules that it cross-links. PMID: 26969727
- These data reveal that hKif15 is a plus-end-directed processive homotetramer that can step against loads of up to 3.5 pN. PMID: 24668168
- Eg5, Kif15, and dynein work together to build a bipolar spindle and reveal an important role for antagonistic motors in chromosome segregation. PMID: 25127142
- regulates alpha2 integrin internalization PMID: 24659801
- Although Kif15 contains ADP in the catalytic site, its motor-domain structure was captured in the ;ATP-like' configuration, with the neck linker docked to the catalytic core. PMID: 24419385
- By examining Kif15 activity in two cellular contexts, it was found that Kif15 bound to kinetochore fibers antagonizes centrosome separation while Kif15 bound to nonkinetochore MTs mediates centrosome separation. PMID: 23791727
- Pole separation depends on Hklp2/Kif15, an otherwise dispensable plus end-directed spindle motor and results in spindles with two centrosomal poles. PMID: 22024925
- Kif15 can replace all essential functions of Eg5 in bipolar spindle assembly. PMID: 19818618
- Hklp2 participates in the assembly and stabilization of the bipolar spindle. PMID: 19818619
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亞細(xì)胞定位：Cytoplasm. Cytoplasm, cytoskeleton, spindle.
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蛋白家族：TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KLP2 subfamily
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組織特異性：Expressed in testis, colon, thymus and in breast cancer.
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數(shù)據(jù)庫(kù)鏈接：
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