KDM4C Antibody

中文名稱：

KDM4C兔多克隆抗體
貨號：

CSB-PA872489HA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA872489HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA872489HA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KDM4C Polyclonal antibody
Uniprot No.：

Q9H3R0
基因名：

KDM4C
別名：

bA146B14.1 antibody; GASC 1 protein antibody; GASC-1 protein antibody; GASC1 antibody; Gene amplified in squamous cell carcinoma 1 protein antibody; JHDM3C antibody; JmjC domain containing histone demethylation protein 3C antibody; JmjC domain-containing histone demethylation protein 3C antibody; JMJD2C antibody; Jumonji domain containing 2C antibody; Jumonji domain containing protein 2C antibody; Jumonji domain-containing protein 2C antibody; Kdm4c antibody; KDM4C_HUMAN antibody; Lysine (K) specific demethylase 4C antibody; Lysine demethylase 4C antibody; Lysine-specific demethylase 4C antibody; TDRD14C antibody; Tudor domain containing 14C antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Lysine-specific demethylase 4C protein (450-600AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，KDM4C Antibody (CSB-PA872489HA01HU)，的標記方式是Non-conjugated。對于KDM4C Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA872489HB01HU	KDM4C Antibody, HRP conjugated	ELISA
FITC	CSB-PA872489HC01HU	KDM4C Antibody, FITC conjugated
Biotin	CSB-PA872489HD01HU	KDM4C Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
基因功能參考文獻：
1. JMJD2C regulated the activities of lung cancer cells by directly controlling the expression of CUL4A in JMJD2C over-expression cell line. PMID: 28236704
2. histone H3 lysine 9 methylation reduction, which may be due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase KDM4C, was found in CD4(+) T lymphocytes of Latent autoimmune diabetes in adult patients PMID: 28396876
3. KDM4C recognition of H3K4me3 stimulates demethylation of H3K9me3 in cis on peptide and mononucleosome substrates. PMID: 26747609
4. Pharmacological inhibition of KDM4C/PRMT1 suppresses transcription and transformation ability of MLL fusions PMID: 26766589
5. Data suggest that D396N polymorphism of JmjC domain-containing histone demethylase JMJD2C affects the prognosis of breast cancer by altering caspase-3 cleavage and the ability of double strand DNA break repair which may contribute to therapy resistance. PMID: 24952432
6. GASC1 expression is higher in adenocarcinoma than squamous cell carcinoma. Smoking decreases GASC1 expression in tumor cells, indicating that tobacco smoke may influence the methylation of histone 3 lysine residues in lung cancer. PMID: 24371038
7. KDM4C promotes transcriptional activation by removing the repressive histone mark, H3K9me3, from its target genes. Variation in its expression leads to differences in the growth of normal and some cancer cells. PMID: 24285722
8. KDM4C maintains the sphere-forming capacity in CRCs by mediating the beta-catenin-dependent transcription of JAG1 in a feed-forward manner. PMID: 23698634
9. analysis of the nickel-induced inhibition of truncated constructs of JMJD2A and JMJD2C histone demethylases using X-ray absorption spectroscopy PMID: 23692052
10. Patients with GASC1 positive tumors have better breast cancer specific survival and respond better to radiotherapy and hormonal treatment PMID: 23148692
11. JMJD2C decreases trimethylation of histone H3 at lysine 9, and enhances HIF-1 binding to hypoxia response elements, thereby activating transcription of proteins that are required for metabolic reprogramming and for lung metastasis. PMID: 23129632
12. JMJD2C displays an optimal activity in vitro at alphaKG concentrations similar to those found in cancer cells, with implications for the regulation of histone demethylation activity in cancer versus normal cells. PMID: 23067339
13. This study presented that KDM4C showed strong associations with alcohol withdrawal symptoms (p < 5 x 10-5). PMID: 22072270
14. inhibition measurements showed significant selectivity between KDM4C and KDM6A PMID: 21575637
15. The strongest association in obsessive-compulsive disorder has been found at rs301443 (P=0.000067) residing between SLC1A1 and JMJD2C at 9p24. PMID: 20410850
16. GASC1 interacts with H3K9me3; three members of this subfamily of proteins demethylate H3K9me3/me2 in vitro through a hydroxylation reaction requiring iron and alpha-ketoglutarate as cofactors PMID: 16732293
17. JMJD2C is the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. PMID: 17611647
18. Gene rearrangements of JMJD2C is associated with mucosa-associated lymphoid tissue lymphoma. PMID: 18927281
19. GASC1 is a driving oncogene in the 9p23-24 amplicon in human breast cancer. PMID: 19784073
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亞細胞定位：

Nucleus.
蛋白家族：

JHDM3 histone demethylase family
組織特異性：

Overexpressed in several esophageal squamous cell carcinomas (ESCs).
數據庫鏈接：

HGNC: 17071

OMIM: 605469

KEGG: hsa:23081

STRING: 9606.ENSP00000370710

UniGene: Hs.709425

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