KDM2B Antibody, HRP conjugated
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中文名稱：KDM2B兔多克隆抗體, HRP偶聯(lián)
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貨號：CSB-PA836777LB01HU
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規(guī)格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) KDM2B Polyclonal antibody
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Uniprot No.：
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基因名：KDM2B
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別名：[Histone-H3]-lysine-36 demethylase 1B antibody; CXXC-type zinc finger protein 2 antibody; CXXC2 antibody; F box and leucine rich repeat protein 10 antibody; F box protein FBL10 antibody; F-box and leucine-rich repeat protein 10 antibody; F-box protein FBL10 antibody; F-box/LRR-repeat protein 10 antibody; Fbl10 antibody; FBXL10 antibody; JEMMA (Jumonji domain EMSY interactor methyltransferase motif) protein antibody; JHDM1B antibody; JmjC domain-containing histone demethylation protein 1B antibody; Jumonji C domain containing histone demethylase 1B antibody; Jumonji domain-containing EMSY-interactor methyltransferase motif protein antibody; kdm2b antibody; KDM2B_HUMAN antibody; Lysine (K) specific demethylase 2B antibody; Lysine-specific demethylase 2B antibody; PCCX2 antibody; Protein containing CXXC domain 2 antibody; Protein JEMMA antibody; Protein-containing CXXC domain 2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Lysine-specific demethylase 2B protein (1274-1336AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).
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基因功能參考文獻：
- Data indicate a cell regulatory mechanism through which lysine-specific demethylase 2B (KDM2B) promotes triple negative breast cancer (TNBC) cell proliferation by binding to the promoters of cell cycle inhibitors p15INK4B, p16INK4A, and p57KIP2. PMID: 30060056
- SS18-SSX1 deregulates developmental programs to drive transformation by hijacking a transcriptional repressive complex to aberrantly activate gene expression PMID: 29502955
- KDM2B regulates EZH2 and BMI1 in HCT116 colon tumor cells. Knockdown of this epigenetic factor induced potent up-regulation of the protein levels of the epithelial markers E-cadherin and ZO-1, while the mesenchymal marker N-cadherin was downregulated. PMID: 29772566
- These results establish a clear functional link between the epigenetic factor KDM2B and the regulation of cell adhesion and Rho-GTPases signaling that controls actin reorganization and cell migration. PMID: 29408056
- The apoptosis phenotype was partly dependent on HRK upregulation, as HRK knockdown significantly abrogated the sensitization. KDM2B-silenced tumors exhibited slower growth in vivo. Taken together, our findings suggest a novel mechanism, where the key apoptosis components are under epigenetic control of KDM2B in glioblastoma multiforme cells. PMID: 28661478
- Data indicate that the reduction of JmjC domain-containing histone demethylase 1B (JHDM1B) leads to a more aggressive cellular phenotype in mammary gland cells, by virtue of its negative regulatory activity on ribosome biogenesis. PMID: 28415746
- a novel regulatory role of KDM2B in autophagy and cell growth in gastric cancer cells, is reported. PMID: 28506929
- we identified KDM2B, a reader for methylated CpGs, as the target of miR-448 that represses glycolysis and promotes oxidative phosphorylation in gastric cancer PMID: 26989077
- High KDM2B expression is associated with Neuroblastomas. PMID: 28684529
- novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations PMID: 26725323
- A missense mutation in the KDM2B gene is associated with malignant peripheral nerve sheath tumors. PMID: 28124441
- we propose histone demethylase KDM2B and histone methyltransferase SETD1B as the two most plausible candidate genes involved in intellectual disability, autism, epilepsy, and craniofacial anomalies PMID: 27106595
- NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. PMID: 24853546
- KDM2B is an important mediator of hematopoietic cell development and has opposing roles in tumor progression that are dependent on cellular context. PMID: 26808549
- Jhdm1b is a positive regulator of glycolysis, glutaminolysis, and pyrimidine synthesis in HeLa cells. PMID: 25877602
- The protein lysine demethylases Kdm2a and Kdm2b regulate the turnover of non-phosphorylated beta-catenin specifically within the nucleus via direct interaction with the fourth and fifth armadillo repeats. PMID: 26004508
- the KDM2B/let-7b/EZH2 axis is involved in epigenetic regulation in MDS, with direct effects on di- and tri-methylation of H3K27. PMID: 25225797
- KDM2B specifically recognizes non-methylated DNA in CpG islands and recruits the polycomb repressive complex 1 (PRC1). This contributes to histone H2A lysine 119 ubiquitylation and gene repression. PMID: 23256043
- Low JHDM1B expression is associated with breast cancers. PMID: 25273595
- KDM2B, an H3K36 histone demethylase implicated in bypass of cellular senescence and somatic cell reprogramming, is markedly overexpressed in PDAC, with levels increasing with disease grade and stage, and highest expression in metastases. PMID: 23321669
- It was found that JHDM1B mRNA is predominantly expressed in acute myeloid leukemia-derived aldehyde dehydrogenasehigh/CD34+ cells, and that aberrant expression of JHDM1B induces leukemia cell proliferation through modulation of cell cycle progression. PMID: 22086844
- a regulatory role of Fbxl10 in cell morphology, chemokine expression, and the metabolic control of fibroblasts. PMID: 22825849
- A novel functional role for FBXL10 as an anti-apoptotic molecule, and describe a new apoptotic-related pathway that involves NF-jB/FBXL10/c-Fos/ c-FLIP. PMID: 21252908
- Results demonstrate that Fbl10 is a key regulator of c-Jun function. PMID: 17704768
- identification of human JHDM1B as a nucleolar protein; JHDM1B preferentially binds the transcribed region of ribosomal DNA to repress the transcription of ribosomal RNA genes PMID: 17994099
- validated occurrence of an unusual TG 3' splice site in intron 15 PMID: 17672918
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亞細胞定位：Nucleus, nucleolus. Nucleus. Chromosome.
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蛋白家族：JHDM1 histone demethylase family
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