KCNMB1 Antibody, FITC conjugated

說(shuō)明書

中文名稱：

KCNMB1兔多克隆抗體, FITC偶聯(lián)
貨號(hào)：

CSB-PA621958LC01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) KCNMB1 Polyclonal antibody
Uniprot No.：

Q16558
基因名：

KCNMB1
別名：

BK channel beta subunit antibody; BK channel subunit beta 1 antibody; BK channel subunit beta-1 antibody; BKbeta antibody; BKbeta1 antibody; Calcium activated potassium channel subfamily M subunit beta 1 antibody; Calcium activated potassium channel subunit beta 1 antibody; Calcium activated potassium channel subunit beta antibody; Calcium-activated potassium channel antibody; Calcium-activated potassium channel subunit beta antibody; Calcium-activated potassium channel subunit beta-1 antibody; Charybdotoxin receptor subunit beta 1 antibody; Charybdotoxin receptor subunit beta-1 antibody; Hbeta1 antibody; hslo beta antibody; K(VCA)beta 1 antibody; K(VCA)beta antibody; K(VCA)beta-1 antibody; KCMB1_HUMAN antibody; KCNMB 1 antibody; Kcnmb1 antibody; Large conductance Ca2+ activated K+ channel beta 1 subunit antibody; Maxi K channel beta subunit antibody; Maxi K channel subunit beta 1 antibody; Maxi K channel subunit beta-1 antibody; Potassium large conductance calcium activated channel subfamily M beta member 1 antibody; Slo beta 1 antibody; SLO beta antibody; Slo-beta antibody; Slo-beta-1 antibody; subfamily M subunit beta-1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Calcium-activated potassium channel subunit beta-1 protein (40-130AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
基因功能參考文獻(xiàn)：
1. Expression of vascular large-conductance calcium-activated potassium channel Kcnmb1 is regulated by Nrf2 signaling. PMID: 28429615
2. The study demonstrates that both transmembrane domains of BKbeta1 are required to provide the characteristic ion current phenotype of beta1-containing BK channels. PMID: 25275635
3. Data show that two lysine residues that are unique to the N terminus of calcium-activated potassium channel subunit beta-1 were identified to be sufficient for voltage-sensor modulation. PMID: 25825713
4. To determine the relationship between atherosclerosis and KCNMB1, we studied some atherogenic factors affecting vascular tone. Blood of atherosclerotic patients shows increased concentration of 7-ketocholesterol, possibly a harmful lipid to blood vessels. PMID: 25576871
5. Bisphenol A activates BK alpha via an extracellular site and that Bisphenol A-sensitivity is increased by the beta1 subunit. PMID: 24476761
6. In large-conductance calcium-dependent potassium channels, beta1 and beta2 subunits alter the voltage sensing domain-cytosolic domain interface. PMID: 23825428
7. The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently. PMID: 23255603
8. HIF-1alpha increases KCNMB1 expression in response to hypoxia in human pulmonary artery smooth muscle cells by binding to two hypoxia response elements located at -3,540 to -3,311 of the KCNMB1 promoter PMID: 22114151
9. Here we found that KCNMB1 common variant Glu65Lys influences glomerular filtration rate across multiple populations of different clinical characteristics and biogeographic ancestries. PMID: 20861615
10. downregulation of vascular BK-beta(1) expression in diabetes and in high-glucose culture conditions was associated with FOXO-3a/FBXO-dependent increase in BK-beta(1) degradation. PMID: 20966391
11. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype. PMID: 19801679
12. Phosphorylation-dependent functional coupling of hSlo and its hbeta 4 subunit PMID: 11790768
13. have a reset baroreflex. Variants in the gene (KCNMB1) coding for the BK beta1 subunit are associated with baroreflex function. PMID: 12011654
14. mesangial cells contain hbeta1, a BK accessory protein, which confers activation of BK by cGMP kinase. PMID: 12670831
15. Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms. PMID: 12893878
16. We conclude that transient membrane current is generated by a mechanism related to the deactivation, and level of prior activation, of glioma BK channels. PMID: 12962281
17. results reveal the molecular regions in the beta1 and beta2 subunits that determine their differential functional coupling with the pore-forming alpha-subunit PMID: 16446507
18. identified and characterized single nucleotide polymorphisms in the exons, intron/exon junctions, upstream region and 3' untranslated regions of KCNMB1 using denaturing high-performance liquid chromatography combined with direct DNA sequencing PMID: 17496725
19. The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade. PMID: 18418400
20. African American male asthmatics carrying the KCNMB1 818T allele (10% of population) are potentially at risk for greater airway obstruction and increased asthma morbidity. PMID: 18535015
21. The findings suggest that the KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in middle-aged men. PMID: 18854753
22. The KCNMB1 E65K variant is associated with reduced central pulse pressure. PMID: 19050450
23. maxi-K(+) beta1-subunit could contribute to vascular dysregulation in severe obstructive sleep apnea syndrome patients. Leukocyte beta1 expression may be independent readout of hypoxemia that could be useful as molecular marker for impending hypertension. PMID: 19057512
24. Cell membrane stretch and cell volume sensitivity are independently regulated by KCNMB1 (BK) and KCNQ1 channels, respectively. PMID: 19289549
25. genetic polymorphism shows sex-specific association with asthma severity in male african population PMID: 19295429
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亞細(xì)胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

KCNMB (TC 8.A.14.1) family, KCNMB1 subfamily
組織特異性：

Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 6285

OMIM: 603951

KEGG: hsa:3779

STRING: 9606.ENSP00000274629

UniGene: Hs.484099

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