KCNH5 Antibody
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中文名稱：KCNH5兔多克隆抗體
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貨號(hào)：CSB-PA905787
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規(guī)格：￥1090
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圖片：
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Western blot analysis of 1) Rat Brain Tissue-Low Molecular Protein Marker, 2)Rat Brain Tissue-High Molecular Protein Marker, 3) Mouse Brain Tissue-Low Molecular Protein Marker, 4) Mouse Brain Tissue- High Molecular Protein Marker, 5) HepG2-Low Molecular P -
Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using Kv10.2 Rabbit pAb diluted at 1:200. -
Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using Kv10.2 Rabbit pAb diluted at 1:200.
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：KCNH5
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別名：KCNH5 antibody; EAG2Potassium voltage-gated channel subfamily H member 5 antibody; Ether-a-go-go potassium channel 2 antibody; hEAG2 antibody; Voltage-gated potassium channel subunit Kv10.2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthetic Peptide
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-2000 IHC 1:100-200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情
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功能：Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
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基因功能參考文獻(xiàn)：
- EAG2 potassium channel has an evolutionarily conserved function for promoting brain tumor growth. PMID: 26258683
- The observed Ca(2+)-induced proteolytic cleavage of EAG2 channel may act as an adaptive response under physiological and/or pathological conditions. PMID: 25542181
- Study propose that hypomethylation of the placental-specific KCNH5 promoter is frequently associated with KCNH5 expression in melanoma cells. PMID: 24759919
- Our results demonstrate the critical role of the Arg327 residue in stabilizing the channel closed state and explicate for the first time the structural and functional change of a Kv10.2 channel mutation associated with neurological disease. PMID: 24133262
- This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
- Three-dimensional structure of human Kv10.2 ion channel studied by single particle electron microscopy and molecular modeling PMID: 22792721
- molecular identification and characterisation PMID: 12135768
- Methylation of KCNH5 was present in 80% of NSCLC tissues but only in 14% of noncancerous tissues. PMID: 18349282
- data suggest that the 'Per-Ant-Sim' (PAS) and cyclic nucleotide binding (cNBD) domains at the N- and C-termini form interacting oligomers that have roles in channel function PMID: 19172261
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亞細(xì)胞定位：Membrane; Multi-pass membrane protein.
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蛋白家族：Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv10.2/KCNH5 sub-subfamily
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組織特異性：Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.
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數(shù)據(jù)庫鏈接：
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