KCND3 Antibody
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中文名稱：KCND3兔多克隆抗體
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貨號(hào)：CSB-PA936150
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規(guī)格：￥1100
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圖片：
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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA936150(KCND3 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：KCND3
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別名：KCND3; Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv4.3
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Fusion protein of Human KCND3
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
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基因功能參考文獻(xiàn)：
- mutations cause a gainoffunction of KV4.3/KChIP2encoded channels by increasing membrane protein expression and slowing channel inactivation. PMID: 26016905
- Mefloquine is a concentration-dependent Ito and hKv4.3 channel blocker. PMID: 26216464
- Altered Kv4.3 channel localization and/or functioning resulting from SCA19/22 mutations may lead to Purkinje cell loss, neurodegeneration and ataxia. PMID: 25854634
- the interaction of DPP10a, expressed in human atrium, with Kv4.3 channels generates a sustained current component of Ito, which may affect late repolarization phase of atrial action potentials. PMID: 25600224
- Kv4.3 K(+) channel is involved in heart hypertrophy/heart failure independently of its electric function.[review] PMID: 24762397
- Demonstrate SEMA3A as a naturally occurring protein that selectively inhibits Kv4.3 and SEMA3A as a possible Brugada syndrome susceptibility gene through a Kv4.3 gain-of-function mechanism. PMID: 24963029
- maps to chromosome 1p21-q21 and identification in Dutch autosomal dominant cerebellar ataxia family PMID: 12384780
- These results indicate that Kv4.3 is likely the target of discrepin and highlight the importance of the basic residue K13, located in the alpha-helix of the toxin, for current blockage. PMID: 24845726
- findings indicate mutations in KCND3 are not a common cause of disease among rarer types of European cerebellar ataxia; however 2 variants were identified in the SCA cases: p.L450F and p.P614S; mutations in KCND3 can cause 2 allelic disorders, SCA19/22 and Brugada syndrome which may co-occur PMID: 23963749
- Report a KV4.3 gain-of-function mutation in early-onset persistent lone atrial fibrillation. PMID: 23400760
- expression of the sodium (SCN5A) and potassium (KCND3) channels as well as the fibrosis content in the ventricles of heart failure and of non-diseased hearts under different post-mortem intervals PMID: 23036686
- The biophysical characteristics of Kv4.3 channels are strongly dependent on temperature. PMID: 23291429
- This study demonistrated that Mutations in KCND3 cause spinocerebellar ataxia type 22 in chinese and japanese. PMID: 23280837
- This study demonistrated that KCND3 mutations cause SCA19 by impaired protein maturation and/or reduced channel function PMID: 23280838
- KCND3 may serve as a rare genetic substrate in the pathogenesis of autopsy-negative sudden unexplained death (SUD) but not sudden infant death syndrome (SIDS) cases. PMID: 22457051
- Human atrial I(to) and cloned hKv4.3 channels are modulated by EGFR kinase via phosphorylation of the Y136 residue and by Src-family kinases via phosphorylation of the Y108 residue. PMID: 22198508
- Deep insights into the mechanism of the regulation of Kv4.3 K channels and the role of Kv4.3 K channels in cell death. PMID: 22023388
- Kv4.3 macromolecular complex and regulators of KCND3 expression is needed to elucidate the role of the Ito current in the pathogenesis of BrS and other J-wave syndromes. PMID: 21349352
- The "structurally minimal" isoform KChIP2d modulates recovery of K(v)4.3 N-terminal deletion mutant Delta2-39. PMID: 21422811
- our findings suggest that KChIP1 interacts with Kv4.3 in interneurons at the stratum lacunosum-moleculare/radiatum junction PMID: 21129448
- The I(to) activator NS5806 modified Kv4.3/KChIP2 gating in several ways that inhibit current. PMID: 20649599
- KChIP4a functions to promote tetrameric assembly and enhance surface expression of Kv4 channels. PMID: 20550899
- N-linked glycosylation of DPP10 plays an important role in modulating Kv4.3 channel/KCHIP2 complex activities. PMID: 20354865
- Down-regulated atrial KChIP2 and Kv4.3 mRNA expressions in rheumatic heart disease patients with chronic atrial fibrillation might be one of the molecular bases responsible for the down-regulation of the I(to) current density of AF. PMID: 19927631
- Kv4.3 promiscuously assembles with ancillary subunits in vitro, functionally modifying the encoded currents. PMID: 12297301
- Analysis with chimeric proteins between KChIP2 and NCS-1 reveals that the three regions of KChIP2 are necessary and sufficient for its effective binding to Kv4.3 protein PMID: 12928444
- the two arginines in the cytosolic C-terminal domain of alpha-subunits of Kv4 subfamily strongly regulate the voltage dependence of channel activation, inactivation, and recovery PMID: 14645239
- Both Kv4.3 and KChIP2 may contribute to epicardial-endocardial gradients in the transient outward current in normal and failing hearts. PMID: 15498806
- Co-expression of SGK1, but not of SGK2 or SGK3, increased Kv 4.3/KChIP2b channel currents. PMID: 15578212
- Co-expression of DPPX in addition to Kv4.3 and KChIP2a produced similar current kinetics as in human ventricular myocytes PMID: 15890703
- KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2 PMID: 16782062
- the mechanisms involved in Syn1A-K(v) interactions vary significantly between K(v) channels, thus providing a wide scope for Syn1A modulation of exocytosis and membrane excitability PMID: 17506992
- Kv4.3 regulates angiotensin type 1 receptor signaling to the small G-protein Rap-1 PMID: 17725712
- KCND3 mutations were not found to directly cause long QT syndrome. PMID: 18052691
- c-Src-induced Kv4.3 channel activation involves their association in a macromolecular complex PMID: 18620005
- NO and NO donors inhibited I(Kv4.3) in a concentration- and voltage-dependent manner. PMID: 18678642
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相關(guān)疾病：Spinocerebellar ataxia 19 (SCA19); Brugada syndrome 9 (BRGDA9)
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亞細(xì)胞定位：Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection, dendrite.
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蛋白家族：Potassium channel family, D (Shal) (TC 1.A.1.2) subfamily, Kv4.3/KCND3 sub-subfamily
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組織特異性：Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected a
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