KANK2 Antibody, Biotin conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) KANK2 Polyclonal antibody
Uniprot No.：

Q63ZY3
基因名：

KANK2
別名：

KANK2 antibody; ANKRD25 antibody; KIAA1518 antibody; MXRA3 antibody; SIP antibody; KN motif and ankyrin repeat domain-containing protein 2 antibody; Ankyrin repeat domain-containing protein 25 antibody; Matrix-remodeling-associated protein 3 antibody; SRC-1-interacting protein antibody; SIP antibody; SRC-interacting protein antibody; SRC1-interacting protein antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human KN motif and ankyrin repeat domain-containing protein 2 protein (410-585AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation.
基因功能參考文獻(xiàn)：
1. Using whole-exome sequencing, authors identified a homozygous missense c.2009C>T mutation in KANK2 PMID: 24671081
2. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. PMID: 17476305
相關(guān)疾病：

Palmoplantar keratoderma and woolly hair (PPKWH)
亞細(xì)胞定位：

Cytoplasm. Mitochondrion.
組織特異性：

Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).
數(shù)據(jù)庫鏈接：

HGNC: 29300

OMIM: 614610

KEGG: hsa:25959

STRING: 9606.ENSP00000395650

UniGene: Hs.284208

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