IVL Antibody, HRP conjugated
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中文名稱：IVL兔多克隆抗體, HRP偶聯
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貨號：CSB-PA011922LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) IVL Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：INVO_HUMAN antibody; Involucrin antibody; IVL antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Involucrin protein (24-118AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
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基因功能參考文獻：
- Together, these results suggest that GR modulates involucrin expression of keratinocytes by regulating the intracellular signaling network in a ligand-independent manner. PMID: 24515279
- over-expression of Nnat was evident along with involucrin and cytokeratin1 expression PMID: 24252747
- involucrin is up-regulated in psoriatic keratinocytes PMID: 23283814
- KLF4 is part of a multiprotein complex that interacts that the hINV promoter distal regulatory region to drive differentiation-dependent hINV gene expression in epidermis. PMID: 23599428
- Compared with the control, the level of expression of the IVL gene in NCTC 2544 cells was increased after 8 h of treatment with hyaluronic acid or Plantaricin A preparations. PMID: 22742591
- Therefore, together with trichohyalin, the cross-linking due to involucrin is also responsible for the mechanical resistance of the corneous trabeculae present among the empty spaces of the medulla of the human hair. PMID: 22197495
- The authors found that HPV 16 E6 but not E7 repressed IVL promoter activity in proliferating human foreskin keratinocyte cells. PMID: 22333115
- higher expression in the fetal skin than in adult skin PMID: 19701759
- expression of the epidermal differentiation complex genes filaggrin and involucrin was strongly decreased directly by IL-13. PMID: 20208004
- Transcriptional activation of the involucrin gene by calcium in keratinocytes. PMID: 9159190
- involucrin gene contains distinct regulatory elements that regulate expression during epidermal differentiation PMID: 11850802
- transactivation of involucrin by lens epithelium-derived growth factor (LEDGF) PMID: 12126624
- the AP-1 site and the vitamin D response element in the involucrin promoter play important roles in mediating the action of 1,25-dihydroxyvitamin D3 on involucrin expression PMID: 12445200
- p38 delta is the major p38 isoform driving suprabasal hINV gene expression PMID: 12810719
- role for AP1 transcription factors in the regulation of human corneal epithelial cell involucrin gene expression. PMID: 15037572
- human involucrin promoter activity is regulated by green tea polyphenol and curcumin via opposing effects on CCAAT/enhancer-binding protein function PMID: 15044435
- cascade regulates activator protein one, Sp1, and CCATT/enhancer-binding protein transcription factor DNA binding to two discrete involucrin promoter regions, the distal- and proximal-regulatory regions, to regulate involucrin gene expression. PMID: 15191537
- cholesterol depletion alters involucrin gene expression through activation of p38alpha/beta. PMID: 15304097
- YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter. PMID: 15586248
- Involucrin expression of keratinocytes is suppressed by roxithromycin through direct inhibition of AP-1 and indirect inhibition of NF-kappaB. PMID: 16140218
- AP1, Sp1, and C/EBP transcription factors are required for appropriate differentiation-dependent involucrin expression. PMID: 16374477
- involucrin gene expression inhibition by apigenin is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311 PMID: 16982614
- Pyk2 regulation is associated with increased expression of Fra-1 and JunD, activator protein-1 transcription factors known to be required for involucrin expression. PMID: 17205062
- There is a major role for STAT5a in the differentiation of keratinocytes, where it contributes to involucrin expression by activating the PPARgamma signal. PMID: 17330131
- BAG-1L also potentiated transactivation of known vitamin-D-responsive gene promoters, osteocalcin and 24-hydroxylase, and enhanced VDR-dependent transcription and protein expression of the keratinocyte differentiation marker, involucrin. PMID: 17662274
- a large multiprotein complex, which includes Fra-1, p300, P/CAF, junD, junB, and Sp1 acts at the AP1-5 site to produce a synergistic increase in hINV gene expression PMID: 17882273
- These findings indicate that PKCdelta activity for activation of involucrin promoter requires Y(311) and a second tyrosine residue; however, any one of the several tyrosine residues can serve in the secondary role. PMID: 17943181
- PPAR gamma regulates involucrin expression by controlling the AP-1 signal and p38 activation in 1 alpha,25(OH)2D3-induced keratinocyte differentiation. PMID: 18077140
- The expression of loricrin and involucrin in invovled and uninvolved skin of patients with atopic dermatitis is reported. PMID: 18166499
- siRNA for PRKD1 resulted in reduction of mRNA levels of PKD1, altered cell phenotype and promotion of keratinocyte differentiation, demonstrated by increased expression of involucrin and keratin 10 mRNAs PMID: 18259765
- RT-PCR and western blot analysis revealed a delay in the expression of the differentiation markers K1, K10 and involucrin in HaCaT cells compared with normal human keratinocytes PMID: 18637039
- Infection by HPV may alter the differentiation status of the epidermis, leading to earlier involucrin expression PMID: 19515043
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亞細胞定位：Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
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蛋白家族：Involucrin family
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組織特異性：Keratinocytes of epidermis and other stratified squamous epithelia.
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數據庫鏈接：
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