ITSN2 Antibody, Biotin conjugated
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中文名稱：ITSN2兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA873709LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ITSN2 Polyclonal antibody
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Uniprot No.：
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基因名：ITSN2
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別名：ITSN2 antibody; KIAA1256 antibody; SH3D1B antibody; SWAP antibody; Intersectin-2 antibody; SH3 domain-containing protein 1B antibody; SH3P18 antibody; SH3P18-like WASP-associated protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Intersectin-2 protein (940-1209AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.
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基因功能參考文獻：
- These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion. PMID: 28161632
- ITSN2L interacts with RABEP1 and stimulates its degradation in regulation of endocytosis. PMID: 26633357
- The ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins. PMID: 22449706
- ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins. PMID: 23936226
- The sequence and structural alignment of ITSN-2L C2 domain with other members of C2 domain protein family indicate its vital cellular roles in membrane trafficking, the generation of lipid-second messengers and activation of GTPases. Moreover, our data show the possible roles of ITSN-2L C2 domain in regulating the activity of Cdc42. PMID: 23274495
- These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2. PMID: 16394100
- ITSN2C may be specifically expressed in neurons hinting to a physiologic role in neuronal cell function. PMID: 17390067
- We show that the PPLP motif of K15 protein selectively binds the SH3-C domain of an endocytic adaptor protein, Intersectin 2 (ITSN2). PMID: 17696407
- ITSN-2L, a guanine nucleotide exchange factor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane. PMID: 19622753
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亞細胞定位：Cytoplasm.
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組織特異性：Expressed in melanocytes. Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.
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數據庫鏈接：
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