ITGB8 Antibody

說明書

中文名稱：

ITGB8兔多克隆抗體
貨號：

CSB-PA011892ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: ITGB8 antibody at 1.52µg/ml
Lane 1: 293T whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Lane 4: A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 86, 72 kDa
Observed band size: 86 kDa

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA011892ESR1HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ITGB8 Polyclonal antibody
Uniprot No.：

P26012
基因名：

ITGB8
別名：

ITGB8; Integrin beta-8
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Integrin beta-8 protein (43-320AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis.
基因功能參考文獻：
1. ITGB8 is identified as a novel target of miR-26a-5p. PMID: 29746867
2. our results indicate that miR-199a-3p enhances cisplatinsensitivity of ovarian cancer cells through downregulating ITGB8 expression, and miR-199a-3p may serve as a therapeutic target for the treatment of ovarian cancer patients with cisplatin-resistance. PMID: 29436681
3. In cellular model, the microRNA-513a-3p was identified as a novel element targeting ITG-beta8, thereby controlling the protein level and its molecular function in the controlling of migration and pro-inflammatory environment. PMID: 29204818
4. Among Greek and Polish patients with intracerebral hemorrhage, heterozygous individuals with the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes. PMID: 27476161
5. The results demonstrated that the hsa_circ_0046701/miR-142-3p/ITGB8 axis might play critical regulatory roles in the pathogenesis and development of glioma. PMID: 29337055
6. Integrin beta8 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
7. Integrin Beta8 plays a role in the motility of prostate cancer cells. PMID: 25886373
8. data show that integrin beta 8, but not integrin beta 5 or integrin beta 6, protein expression is increased in liver specimens of patients with biliary atresia PMID: 25079481
9. Brain metastases ITGB8 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
10. Desmoglein-2 co-localizes with integrin-beta8 in N-MVECs. PMID: 23874518
11. ITGB8 silencing may change lung cancer cells to a less invasive phenotype through alteration in the expression of metastasis-related genes. PMID: 22753015
12. Deletion of the Itgb8 gene from retinal ganglia cells and Mu ller glia, but not astrocytes, results in highly abnormal vascular patterning and instability. PMID: 22279205
13. Highly angiogenic and poorly invasive glioblastomas expressed low levels of beta8 integrin, whereas highly invasive glioblastomas with limited neovascularization expressed high levels of beta8 integrin. PMID: 21859829
14. Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. PMID: 21878622
15. miR-93 promotes the growth of, and angiogenesis in astrocytomas, by suppressing, at least in part, integrin-beta8 expression. PMID: 20956944
16. Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway PMID: 20519498
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Integrin beta chain family
組織特異性：

Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.
數據庫鏈接：

HGNC: 6163

OMIM: 604160

KEGG: hsa:3696

STRING: 9606.ENSP00000222573

UniGene: Hs.592171

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