INPP5K Antibody

說明書

中文名稱：

INPP5K兔多克隆抗體
貨號：

CSB-PA866277ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA866277ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) INPP5K Polyclonal antibody
Uniprot No.：

Q9BT40
基因名：

INPP5K
別名：

43 kDa form skeletal muscle and kidney enriched inositol phosphatase antibody; Inositol polyphosphate 5-phosphatase K antibody; INP5K_HUMAN antibody; INPP5K antibody; muscle and kidney-enriched inositol phosphatase antibody; PPS antibody; skeletal muscle and kidney enriched inositol phosphatase antibody; Skeletal muscle and kidney-enriched inositol phosphatase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Inositol polyphosphate 5-phosphatase K protein (149-448AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.
基因功能參考文獻：
1. the distribution of genotype frequency exhibited no significant differences between the Parkinson's disease and control groups (P > 0.025) in INPP5K rs1109303 (P = 0.048, OR = 0.806, 95%CI = 0.650 - 0.998). PMID: 29607885
2. In individuals exhibiting congenital muscular dystrophy, early-onset cataracts, and mild intellectual disability but normal cranial magnetic resonance imaging, we identified bi-allelic mutations in INPP5K, encoding inositol polyphosphate-5-phosphatase K. PMID: 28190456
3. Mutations in INPP5K cause a congenital muscular dystrophy syndrome with short stature, cataracts, and intellectual disability. PMID: 28190459
4. These findings suggest a model by which GRP78 regulates intracellular localization of SKIP and how SKIP binds to Pak1 on insulin stimulation. PMID: 26940976
5. Study reveals that SKIP is a significant regulator of glioblastoma cell migration and that increased expression of SKIP may confer a survival advantage. PMID: 25241900
6. SKIP controls the IGF-II-PI 3-kinase-Akt-mTOR auto-regulation loop during myogenesis. PMID: 22815484
7. Specific suppression of insulin signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1. PMID: 22751929
8. identification of novel domain that mediates membrane ruffle localization PMID: 12536145
9. The authors report that HBV core protein interacts with a cellular SKIP (skeletal muscle and kidney enriched inositol phosphatase) protein, an endoplasmic reticulum-located phosphoinositide 5-phosphatase, both in vivo and in vitro. PMID: 18774950
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相關疾病：

Muscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID)
亞細胞定位：

Endoplasmic reticulum. Cytoplasm.
蛋白家族：

Inositol 1,4,5-trisphosphate 5-phosphatase type II family
組織特異性：

Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
數據庫鏈接：

HGNC: 33882

OMIM: 607875

KEGG: hsa:51763

STRING: 9606.ENSP00000413937

UniGene: Hs.632238

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