ILF2 Antibody
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中文名稱：ILF2兔多克隆抗體
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貨號：CSB-PA011683GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：ILF2
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別名：HGNC:6037 antibody; ILF 2 antibody; ilf2 antibody; ILF2_HUMAN antibody; Interleukin enhancer binding factor 2 antibody; Interleukin enhancer binding factor 2; 45kDa antibody; Interleukin enhancer-binding factor 2 antibody; MGC8391 antibody; NF 45 antibody; NF45 antibody; Nuclear factor of activated T cells 45 kDa antibody; Nuclear factor of activated T-cells 45 kDa antibody; PRO3063 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human NF45
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.
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基因功能參考文獻：
- this study identifies a new role of ILF2 in the regulation of the NLRP3 inflammasome. PMID: 29655789
- High expression of ILF2 was tightly correlated with lymph node metastasis, pathological stage and poor clinical prognosis in gastric cancer. PMID: 28831206
- ILF2 interacts with RNA-binding proteins involved in the DNA damage response. PMID: 28669490
- The data suggest that features of both the N- and C-termini of NF90 participate in the heterodimerization with NF45 and that the formation of NF90-NF45 changes the conformation of NF90's RNA-binding motifs to a status in which the co-operative interplay of the RNA-binding motifs is optimal. PMID: 28062840
- NF90-NF45 stimulates an elevation of EGF receptor levels via the suppression of miR-7 biogenesis, resulting in the promotion of cell proliferation in Hepatocellular Carcinoma. PMID: 27519414
- The results revealed that ILF2 is regulated by miR-7 and suggest that downregulation of miR-7 may be an important factor for the ILF2 overexpression in pancreatic carcinoma. PMID: 28259961
- Deletion of the RNA binding domains of NF45 and NF90 diminished the enhancement of HIV infection and gene expression. PMID: 26891316
- NF45 overexpression is associated with poor prognosis and enhanced cell proliferation of pancreatic ductal adenocarcinoma. PMID: 26276310
- Upregulated expression of ILF2 in non-small cell lung cancer is associated with tumor cell proliferation and poor prognosis PMID: 26059795
- The RNA binding complexes NF45-NF90 and NF45-NF110 associate dynamically with the c-fos gene and function as transcriptional coactivators. PMID: 26381409
- NF45 and NF90 are novel higher-eukaryote-specific factors required for the maturation of 60S ribosomal subunits. PMID: 26240280
- These findings suggested that NF45 might play an important role in promoting the tumorigenesis of ESCC, and thus be a promising therapeutic target to prevent ESCC progression. PMID: 25286760
- These results suggest a novel molecular mechanism for the modulation of RNA granule assembly and disassembly by NFAR2, NF45, and phosphorylation at double-stranded RNA-activated kinase PKR sites. PMID: 24920670
- These findings indicate that NF45 plays an important role in the growth regulation of glioma cells PMID: 25023405
- AU-rich 5' UTRs harboring internal ribosome entry sites are regulated by NF45. NF45 regulates XIAP protein levels through interaction with its IRES. PMID: 23129811
- The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining PMID: 21969602
- ILF2 recruits a DNA-associated replication and transcription complex, of which it is a part, to its target DNA sequence. PMID: 20808282
- The data presented are consistent with a model in which translation of cIAP1 is governed, at least in part, by NF45, a novel cellular IRES trans-acting factor. PMID: 19893574
- plays important role in protein priming of HBV polymerase PMID: 11958450
- NF45 is a is a highly conserved transcriptional activator of the gene IL-2. PMID: 15817156
- Cell growth is retarded and giant multinucleated cells accumulate when the expression of NF45 or NF90, but not NF110, is reduced in HeLa cells. PMID: 18458058
- Results suggest that the association of the NF90-NF45 complex with pri-miRNAs impairs access of the Microprocessor complex to the pri-miRNAs, resulting in a reduction of mature miRNA production. PMID: 19398578
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亞細胞定位：Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
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