IL1RAPL1 Antibody, Biotin conjugated
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中文名稱：IL1RAPL1兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA011624LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) IL1RAPL1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：IL 1 RAPL 1 antibody; IL 1RAPL 1 antibody; IL-1-RAPL-1 antibody; IL-1RAPL-1 antibody; IL1R8 antibody; IL1RAPL 1 antibody; IL1RAPL antibody; IL1RAPL-1 antibody; IL1RAPL1 antibody; Interleukin 1 receptor 8 antibody; Interleukin 1 receptor accessory protein like 1 antibody; Interleukin-1 receptor accessory protein-like 1 antibody; IRPL1_HUMAN antibody; Mental retardation X linked 10 antibody; Mental retardation X linked 21 antibody; Mental retardation X linked 34 antibody; MRX 21 antibody; MRX 34 antibody; MRX10 antibody; MRX21 antibody; MRX34 antibody; Oligophrenin 4 antibody; Oligophrenin-4 antibody; Oligophrenin4 antibody; OPHN 4 antibody; OPHN4 antibody; Three immunoglobulin domain containing IL 1 receptor related 2 antibody; Three immunoglobulin domain-containing IL-1 receptor-related 2 antibody; TIGIRR 2 antibody; TIGIRR-2 antibody; TIGIRR2 antibody; X linked interleukin 1 receptor accessory protein like 1 antibody; X-linked interleukin-1 receptor accessory protein-like 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Interleukin-1 receptor accessory protein-like 1 protein (564-679AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.
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基因功能參考文獻：
- Our study revealed that the expression of IL-1R8 significantly increased on in vitro-activated CD4+ T cells and was markedly higher on CD4+ T cells from allergic rhinitis patients than on cells from healthy controls. PMID: 29730558
- IL-1R8 serves as a checkpoint for NK cell maturation and effector function; its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection in mice PMID: 29072292
- Altered DNA methylation in IL1RAPL1 involves in the etiology of Bipolar disorder and Major Depressive disorder . PMID: 27440233
- rs12007907 variant in IL1RAPL gene was negatively associated with asthma and IL-13 production in Latin American children. PMID: 28120837
- Our study expands the molecular repertoire of IL1RAPL1 mutations in intellectual disability and points out the need of more accurate clinical descriptions to better define the related phenotype PMID: 27470653
- It was indicated that a defect in IL1RAPL1 that controls excitatory synapsis formation results in the excitation-inhibition balance affecting various cerebral functions. PMID: 25864829
- Novel IL1RAPL1 mutations associated with intellectual disability impair synaptogenesis. PMID: 25305082
- The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling. PMID: 21926414
- The IL1RAPL1 gene is of interest as a candidate gene for autism spectrum disorder as mutations or deletions in the gene have previously been reported in individuals from families with ASD. PMID: 21491612
- Intragenic deletions in IL1RAPL1are relevant to the pathogenesis of X-linked mental retardation. PMID: 21271657
- crystal structure at 2.3-A resolution of the TIR domain of IL-1RAPL PMID: 15123616
- Nearly all patients with deletions involving DAX1, but not DMD, had mental retardation if IL1RAPL1 was deleted. If ILIRAPLI & DMD were intact, the patients with DAX1 deletions only rarely had normal development. PMID: 15300857
- Report confirms the role of the IL1RAPL1 gene in causing nonspecific mental retardation in males. PMID: 16470793
- DMD gene and its immediately distal neighbor, the 1.8 Mb IL1RAPL1 gene are abundantly expressed in normal brain but were dramatically underexpressed in every brain tumor cell line and xenograft. PMID: 18253029
- Combined data suggested that IL1RAPL1 affected human cognitive ability to some extent, especially the memory and concentration capability. PMID: 18467032
- The function of truncated IL1RAPL1 protein in an autistic female with Asperger syndrome is severely altered in hippocampal neurons, demonstrated by its effect on neurite outgrowth activity. PMID: 18801879
- IL1RAPL1 plays an important role in the etiology of X-linked mental retardation. PMID: 19012350
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相關疾病：Mental retardation, X-linked 21 (MRX21)
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, axon. Cell projection, dendrite.
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蛋白家族：Interleukin-1 receptor family
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組織特異性：Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal live
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