IGSF8 Antibody

說明書

中文名稱：

IGSF8兔多克隆抗體
貨號：

CSB-PA005881
規(guī)格：

￥1090
圖片：
Western Blot analysis of NIH-3T3 cells using CD316 Polyclonal Antibody.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q969P0
基因名：

IGSF8
別名：

CD316 antibody; CD316 antigen antibody; CD81 partner 3 antibody; CD81P3 antibody; EWI-2 antibody; EWI2 antibody; Glu-Trp-Ile EWI motif-containing protein 2 antibody; igsf-8 antibody; IgSF8 antibody; IGSF8_HUMAN antibody; Immunoglobulin superfamily member 8 antibody; Immunoglobulin superfamily member 8 precursor antibody; KCT-4 antibody; KCT4 antibody; Keratinocytes-associated transmembrane protein 4 antibody; LIR-D1 antibody; PGRL antibody; Prostaglandin regulatory-like protein antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human CD316.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
基因功能參考文獻：
1. EWI-2 negatively regulates TGF-beta signaling and its downstream events including cytostasis (in vitro and in vivo), EMT-like changes, cell migration, CD271-dependent invasion, and lung metastasis (in vivo). PMID: 25656846
2. Authors demonstrated that EWI-2wint promotes CD81 clustering and confinement in CD81-enriched areas. PMID: 23351194
3. The EWI-2/alpha-actinin complex is involved in regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and the formation of polarized membrane structures involved in T cell recognition. PMID: 22689882
4. analysis of interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection PMID: 21343309
5. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. PMID: 12750295
6. EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions PMID: 15070678
7. EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization PMID: 16537545
8. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins PMID: 16690612
9. Important functions of recently activated dendritic cells are thus critically modulated by the newly discovered HSPA8-EWI-2 interaction. PMID: 17785435
10. CD81 partner EWI-2wint inhibits hepatitis C virus entry [EWI-2wint] PMID: 18382656
11. EWI-2 causes a substantial molecular reorganization of multiple molecules known to affect proliferation and/or invasion of astrocytes and/or glioblastomas. PMID: 19107234
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亞細胞定位：

Cell membrane; Single-pass membrane protein.
組織特異性：

Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.
數(shù)據(jù)庫鏈接：

HGNC: 17813

OMIM: 606644

KEGG: hsa:93185

STRING: 9606.ENSP00000316664

UniGene: Hs.332012

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