IFIT5 Antibody

文獻引用 (1) 說明書

中文名稱：

IFIT5兔多克隆抗體
貨號：

CSB-PA011023LA01HU
規格：

￥440
圖片：
Western blot
All lanes: IFIT5 antibody at 2µg/ml
Lane 1: A375 whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 56, 51 kDa
Observed band size: 56 kDa

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA011023LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA011023LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) IFIT5 Polyclonal antibody
Uniprot No.：

Q13325
基因名：

IFIT5
別名：

FLJ53857 antibody; FLJ92678 antibody; IFIT-5 antibody; IFIT5 antibody; IFIT5_HUMAN antibody; Interferon induced protein with tetratricopeptide repeats 5 antibody; Interferon-induced protein with tetratricopeptide repeats 5 antibody; Retinoic acid and interferon inducible 58 kDa protein antibody; Retinoic acid and interferon inducible protein (58kD) antibody; Retinoic acid- and interferon-inducible 58 kDa protein antibody; RI58 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Interferon-induced protein with tetratricopeptide repeats 5 protein (107-320AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，IFIT5 Antibody (CSB-PA011023LA01HU)，的標記方式是Non-conjugated。對于IFIT5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA011023LB01HU	IFIT5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA011023LC01HU	IFIT5 Antibody, FITC conjugated
Biotin	CSB-PA011023LD01HU	IFIT5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection Garcia-Moreno M, et al,Molecular Cell,2019

產品評價

靶點詳情

功能：

Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and selectively binds AT-rich dsDNA. Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7.
基因功能參考文獻：
1. IFIT5 promotes SeV-induced IKK phosphorylation and NF-kappaB activation by regulating the recruitment of IKK to TAK1. PMID: 26334375
2. show that IFIT5 binds precursor and processed tRNAs, as well as other RNA polymerase III transcripts. Our findings establish the RNA recognition specificity of the human innate immune response protein IFIT5 PMID: 25092312
3. TRIF-N-terminal helical domain shares structural similarity with IFIT5. PMID: 24311583
4. IFIT5 consists of 24 alpha-helices that pack into a special "V"-like structure. PMID: 23774268
5. IFIT5 recognizes cellular RNA instead of protein partners. PMID: 23317505
6. crystal structures of human IFIT5, its complex with PPP-RNAs, and an amino-terminal fragment of IFIT1 PMID: 23334420
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亞細胞定位：

Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.
蛋白家族：

IFIT family
數據庫鏈接：

HGNC: 13328

OMIM: 616135

KEGG: hsa:24138

STRING: 9606.ENSP00000360860

UniGene: Hs.252839

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