HYOU1 Antibody
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中文名稱：HYOU1兔多克隆抗體
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貨號：CSB-PA896895ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA896895ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA896895ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HYOU1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：150 kDa oxygen regulated protein antibody; 150 kDa oxygen-regulated protein antibody; 170 kDa glucose regulated protein antibody; 170 kDa glucose-regulated protein antibody; DKFZp686N08236 antibody; FLJ94899 antibody; FLJ97572 antibody; glucose regulated protein 170 antibody; Grp 170 antibody; GRP-170 antibody; Grp170 antibody; HSP 12A antibody; HSP12A antibody; Hyou1 antibody; HYOU1_HUMAN antibody; Hypoxia up regulated 1 antibody; hypoxia up-regulated 1 precursor antibody; Hypoxia up-regulated protein 1 antibody; Hypoxia upregulated 1 antibody; Orp 150 antibody; ORP-150 antibody; Orp150 antibody; oxygen regulated protein (150kD) antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Hypoxia up-regulated protein 1 protein (1-140AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
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基因功能參考文獻：
- These results strongly suggest that AMPK can activate ORP150 through FOXO1 pathway and confer protection against endoplasmic reticulum stress - induced apoptosis of airway epithelial cells following exposure to cigarette smoke extract. PMID: 29448096
- Findings establish a general function of Grp170 during ERAD and suggest that positioning this client-release factor at the retrotranslocation site may afford a mechanism to couple client release from BiP and retrotranslocation. PMID: 27030672
- Data reveal that Grp170 participates in preparing mutant proinsulin for degradation while enabling wild-type proinsulin escape from the endoplasmic reticulum. PMID: 28028074
- High ORP150 expression is associated with thyroid cancer. PMID: 26700459
- Two NEFs, Grp170 and Sil1, trigger toxin release from BiP to enable successful retrotranslocation and clarify the fate of the toxin after it disengages from BiP. PMID: 25877869
- Grp170 induces nucleotide exchange of BiP and releases SV40 virus from BiP, promoting SV40 ER-to-cytosol transport and infection. PMID: 25653441
- HYOU1 also modulates vIL-6's ability to induce CCL2. PMID: 24920810
- Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins. PMID: 24327659
- inducible overexpression of ORP150, in ER stress conditions, exerts inhibitory effect on apoptosis and senescence in human breast carcinoma cells but not in normal fibroblasts PMID: 23757447
- Data indicate that Grp170 (Lhs1 ortholog) coprecipitate with alphaENaC. PMID: 23645669
- AICAR infusion enhanced ORP150 expression, resulting in the marked amelioration of hepatic ER stress and apoptosis PMID: 21296878
- Report ORP-150 levels in autopsy tissue after hypoxia/ischemia events in term neonates. PMID: 20626887
- ORP150 exerts cytoprotective effects in renal tubular epithelia subjected to I/R injury and suggest a key role for ER stress in the renal tubular response to acute renal failure PMID: 15240565
- Hypoxia results in an enhancement of ORP 150 expression in several tumour cell lines. PMID: 16543725
- These findings suggest that ORP150 is structurally and functionally well conserved in distant species PMID: 17131193
- Our observations led to the hypothesis that ORP150 protects against MPTP/MPP(+)-induced neurotoxicity, and indicate the importance of the ER environment in maintaining the nigrostriatal pathways. PMID: 17330988
- data indicate ORP150 inhibits oxLDL-induced apoptosis by blocking calcium signaling & apoptosis; calcium released from ER stores is inhibited by ORP150; ORP150 is expressed in advanced atherosclerotic lesions PMID: 18404158
- The forced expression of ORP150 highlights its new protective role against oxLDL-induced ER stress and subsequent apoptosis PMID: 19106412
- the increased expression of ORP150 is a factor which protects collagen against intracellular degradation induced by glucose deprivation. PMID: 19225868
- The ORP150-precursor peptide complex can elicit a cytotoxic T-lymphocyte response through cross-presentation, as well as the CD4-positive T cell response by dendritic cells. PMID: 19812200
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亞細胞定位：Endoplasmic reticulum lumen.
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蛋白家族：Heat shock protein 70 family
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組織特異性：Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic
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數據庫鏈接：
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