HTR2B Antibody
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中文名稱：HTR2B兔多克隆抗體
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貨號：CSB-PA004148
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規格：￥1090
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圖片：
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Western Blot analysis of HeLa cells using SR-2B Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：HTR2B; 5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; Serotonin receptor 2B
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the N-terminal region of Human SR-2B.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
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基因功能參考文獻：
- The biological role of 5-HT2B which may act not only as a neurotransmitter receptor. PMID: 29379077
- The 3.0-A resolution structure of a complex between the human 5-hydroxytryptamine 2B (5-HT2B) receptor and an antibody Fab fragment bound to the extracellular side of the receptor reveals the mechanism of selectivity in extracellular recognition of the receptor by monoclonal antibodies. PMID: 28716900
- MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC. PMID: 27301951
- The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin sensitivity among HTR2B Q20* carriers with low testosterone levels. PMID: 27420381
- Study describes the crystal structure of Lysergic acid diethylamide (LSD) in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational selectivity of LSD's key diethylamide moiety. PMID: 28129538
- The 5-HT2B receptor may contribute to the regulation of human glucagon and glucose homeostasis and the interplay between glucagon and insulin secretion. PMID: 27437919
- Authors hypothesize that HTR2B expression in the infarcted territory may render degenerating neurons susceptible to attack by activated microglia and thus aggravate the consequences of stroke. PMID: 27013593
- Activation of 5-HT2B receptors stimulates GSIS in beta cells by triggering downstream changes in cellular Ca(2+) flux that enhance mitochondrial metabolism. PMID: 26733006
- the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in amyotrophic lateral sclerosis PMID: 26744351
- Studies have found that the HTR2B Q20* connected with impulsive behavior and cognitive impulsivity. PMID: 26575222
- Data indicate that hydrogen bonding interactions with Ser3.36 and Thr3.37 were important for isoflurane binding with the 5HT2B receptor. PMID: 24365264
- results of the present study suggest that the HTR2B polymorphism is not likely to be associated with personality traits, including novelty seeking and impulsivity. PMID: 23774082
- a new and unanticipated role of the 5-HT2B receptor N terminus as a negative modulator, affecting both constitutive and agonist-stimulated activity. PMID: 24174497
- study determined the crystal structure of the 5-HT2B receptor bound to ergotamine (ERG) and compared it with the 5-HT1B/ERG structure PMID: 23519215
- Serotonin skews human macrophage polarization through HTR2B and HTR7. PMID: 23355731
- The HTR2B gene may play little or no role in the development of Tourette syndrome. PMID: 22917605
- Genetic variants in HTR2B and TPH1 were not associated with the risk of GDM. PMID: 21836641
- Study confirms expression of transgenic 5-HT2b receptors in astrocytes freshly dissociated from mouse brain, isolated by fluorescence-activated cell sorting (FACS) and investigated in cultured cells. PMID: 20846463
- indicates a role for HTR2B in impulsivity PMID: 21179162
- The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment PMID: 20564397
- The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis. PMID: 11859080
- the excitatory effects of 5-HT in human colon are mediated by 5-HT(2B) receptors. 5-HT(2B) receptors contribute to the putative 5-HT-induced colonic smooth muscle hypersensitivity associated with irritable bowel syndrome. PMID: 11877320
- Expression in cultured skin cells. PMID: 12767050
- 5-HT2B single nucleotide polymorphisms have significant association with substance-related disorders. PMID: 15608559
- Interactions between AT(1) and 5-HT(2B) receptors coexpressed by noncardiomyocytes are limiting key events in adrenergic agonist-induced, angiotensin-dependent cardiac hypertrophy. PMID: 19023134
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亞細胞定位：Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
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蛋白家族：G-protein coupled receptor 1 family
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組織特異性：Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
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數據庫鏈接：
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