HTN3 Antibody

中文名稱：

HTN3兔多克隆抗體
貨號：

CSB-PA010879NA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA010879NA01HU diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HTN3 Polyclonal antibody
Uniprot No.：

P15516
基因名：

HTN3
別名：

HTN3 antibody; HIS2 antibody; Histatin-3 antibody; Basic histidine-rich protein antibody; Hst antibody; Histidine-rich protein 3 antibody; PB) [Cleaved into: Histatin-3; His3-(20-44)-peptide antibody; His3 20/44 antibody; His3-(1-25)-peptide antibody; His3 1/25 antibody; Histatin-3 1/25 antibody; Histatin-6); His3-(20-43)-peptide antibody; His3 20/43 antibody; His3-(1-24)-peptide antibody; His3 1/24 antibody; Histatin-3 1/24 antibody; Histatin-5); His3-(20-32)-peptide antibody; His3 20/32 antibody; His3-(1-13)-peptide antibody; His3 1/13 antibody; Histatin-3 1/13); His3-(20-31)-peptide antibody; His3 20/31 antibody; His3-(1-12)-peptide antibody; His3 1/12 antibody; Histatin-3 1/12); His3-(20-30)-peptide antibody; His3 20/30 antibody; His3-(1-11)-peptide antibody; His3 1/11 antibody; Histatin-3 1/11); His3-(24-32)-peptide antibody; His3 24/32 antibody; His3-(5-13)-peptide antibody; His3 5/13 antibody; Histatin-3 5/13); His3-(24-31)-peptide antibody; His3 24/31 antibody; His3-(5-12)-peptide antibody; His3 5/12 antibody; Histatin-11 antibody; Histatin-3 5/12); His3-(24-30)-peptide antibody; His3 24/30 antibody; His3-(5-11)-peptide antibody; His3 5/11 antibody; Histatin-12 antibody; Histatin-3 5/11); His3-(25-32)-peptide antibody; His3 25/32 antibody; His3-(6-13)-peptide antibody; His3 6/13 antibody; Histatin-3 6/13); His3-(25-30)-peptide antibody; His3 25/30 antibody; His3-(6-11)-peptide antibody; His3 6/11 antibody; Histatin-3 6/11); His3-(26-32)-peptide antibody; His3 26/32 antibody; His3-(7-13)-peptide antibody; His3 7/13 antibody; Histatin-3 7/13); His3-(26-31)-peptide antibody; His3 26/31 antibody; His3-(7-12)-peptide antibody; His3 7/12 antibody; Histatin-3 7/12); His3-(26-30)-peptide antibody; His3 26/30 antibody; His3-(7-11)-peptide antibody; His3 7/11 antibody; Histatin-3 7/11); His3-(31-51)-peptide antibody; His3 31/51 antibody; His3-(12-32)-peptide antibody; His3 12/32 antibody; Histatin-3 12/32 antibody; Histatin-4); His3-(31-44)-peptide antibody; His3 31/44 antibody; His3-(12-25)-peptide antibody; His3 12/25 antibody; Histatin-3 12/25 antibody; Histatin-9); His3-(31-43)-peptide antibody; His3 31/43 antibody; His3-(12-24)-peptide antibody; His3 12/24 antibody; Histatin-3 12/24 antibody; Histatin-7); His3-(32-44)-peptide antibody; His3 32/44 antibody; His3-(13-25)-peptide antibody; His3 13/25 antibody; Histatin-10 antibody; Histatin-3 13/25); His3-(32-43)-peptide antibody; His3 32-43 antibody; His3-(13-24)-peptide antibody; His3 13/24 antibody; Histatin-3 13/24 antibody; Histatin-8); His3-(33-44)-peptide antibody; His3 33/44 antibody; His3-(14-25)-peptide antibody; His3 14/25 antibody; Histatin-3 14/25); His3-(33-43)-peptide antibody; His3 33/43 antibody; His3-(14-24)-peptide antibody; His3 14/24 antibody; Histatin-3 14/24); His3-(34-44)-peptide antibody; His3 34/44 antibody; His3-(15-25)-peptide antibody; His3 15/25 antibody; Histatin-3 15/25); His3-(34-43)-peptide antibody; His3 34/43 antibody; His3-(15-24)-peptide antibody; His3 15/24 antibody; Histatin-3 15/24); His3-(45-51)-peptide antibody; His3 45/51 antibody; His3-(26-32)-peptide antibody; His3 26/32 antibody; Histatin-3 26/32); His3-(47-51)-peptide antibody; His3 47/51 antibody; His3-(28-32)-peptide antibody; His3 28/32 antibody; Histatin-3 28/32); His3-(48-51)-peptide antibody; His3 48/51 antibody; His3-(29-32)-peptide antibody; His3 29/32 antibody; Histatin-3 29/32)] antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Peptide sequence from Human Histatin-3 protein (20-34AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，HTN3 Antibody (CSB-PA010879NA01HU)，的標記方式是Non-conjugated。對于HTN3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA010879NB01HU	HTN3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA010879NC01HU	HTN3 Antibody, FITC conjugated
Biotin	CSB-PA010879ND01HU	HTN3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Antigen Affinity purified & Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
基因功能參考文獻：
1. This aim of this study was to identify novel biomarkers using comparative global proteome analysis to improve the risk assessment for recurrent coronary events. Beta -defensin-128 and histatin-3 may be potential biomarkers whch may be used to improve risk the stratification for recurrent coronary events. PMID: 28627688
2. the availability of Cu during exposure of Candida albicans to histatin-5 (Hist-5) modulates its antifungal activity. PMID: 28763199
3. The aim of this study was to achieve a molecular understanding and a physico-chemical insight of the obtained small angle X-ray scattering and to gain information of the conformational changes of Histatin 5 due to altering salt content, charge distribution, and net charge. PMID: 26914439
4. Histatin 5 Salivary Complexes PMID: 26544073
5. Hst 5 may affect mitochondrial functions and cause oxidative stress; however, the ultimate cause of cell death is by volume dysregulation and ion imbalance triggered by osmotic stress. [Review] PMID: 24951439
6. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
7. analysis of histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins PMID: 22033918
8. Histatin-5 is a likely transport molecule for toxic Ni(II) in human saliva.Its binding constant to nickel is five time higher than that of albumin. PMID: 21741339
9. Hst 5 binding to beta-glucans on the cell wall of C. albicans is salt-sensitive. Uptake of Hst 5 shows dose-dependent translocation and intracellular accumulation precede vacuole expansion and propidium iodide uptake. PMID: 20487276
10. Killing of Candida albicans requires cellular uptake and energy metabolism (Histatin 5) PMID: 11816973
11. caused a loss of cell viability concomitant with a decrease in cellular volume as determined both by a classical candidacidal assay with exogenous Hst 5 and by using a genetically engineered C. albicans strain expressing Hst 5 (salivary histatin 5) PMID: 12183519
12. study provides evidence for a novel function for yeast Ssa1/2 heat-shock proteins as cell envelope binding receptors for histatin 5 that mediate fungicidal activity PMID: 12761219
13. results suggest that the genesis of histatin 3-related peptides, being under the principal action of trypsin-like activities, is probably not a random process but rather follows a sequential fragmentation pathway; cleavage sites are identified PMID: 15272024
14. A 20-residue-derived histatin 5 peptide preserves anticandidal activity, binds DNA, and has nuclease activity in the presence of copper and zinc ions. PMID: 17176059
15. Two cationic lysine residues at positions 2 and 10 in the P-113 peptide of Histatin 5 are important for transport into the cytosol of Candida albicans and that binding and transport are independent functional events. PMID: 17999963
16. key steps of its lethal mechanism against parasites PMID: 18230684
17. Gene polymorphism at codon 23 of the histatin 3 gene was not associated with periodontitis in the Japanese population. Rather it appeared to be associated with resistance to periodontitis. PMID: 19753800
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亞細胞定位：

Secreted. Note=Secreted by serous acinar and demilune cells.
蛋白家族：

Histatin/statherin family
數據庫鏈接：

HGNC: 5284

OMIM: 142702

KEGG: hsa:3347

STRING: 9606.ENSP00000432561

UniGene: Hs.654442

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